Approaching pre-diabetes

Journal of Diabetes and Its Complications
Leigh Perreault, Kristine Færch

Abstract

As the global epidemic of type 2 diabetes continues to rise, the time has come to revisit our approach to pre-diabetes. Recently, much ado has been made about screening, diagnosis, pathophysiology and clinical interventions in pre-diabetes, and all for good reason as the key to reversing the diabetes epidemic likely lies therein. The somewhat controversial term "pre-diabetes" represents collective dysglycemic states intermediate between normal glucose regulation (NGR) and diabetes. Not all people with pre-diabetes will develop diabetes, but the majority will. In fact, up to 70% of those with pre-diabetes may acquire the disease over their lifetime. Furthermore, even when overt diabetes is delayed or prevented, both micro- and macrovascular disease appears more prevalent in those with pre-diabetes compared to their normoglycemic peers. Hence, there is growing consensus that NGR should be the goal for people with pre-diabetes. Nevertheless, there is much to consider in that pursuit. Herein, we provide an update on the global burden of pre-diabetes, its underlying pathophysiology and discuss clinical considerations in these individuals at high risk of developing diabetes.

References

Apr 6, 2001·Diabetes Care·S H SaydahF L Brancati
May 10, 2001·JAMA : the Journal of the American Medical Association·F de VegtR J Heine
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Nov 25, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·Q QiaoJ Tuomilehto
Oct 7, 2005·The New England Journal of Medicine·Amir TiroshUNKNOWN Israeli Diabetes Research Group
Nov 2, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·UNKNOWN Diabetes Prevention Program Research GroupReubin Andres
Jan 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·UNKNOWN Diabetes Prevention Program Research Group
Mar 1, 2007·Diabetes Care·David M NathanUNKNOWN American Diabetes Association
Mar 1, 2007·The Journal of Clinical Endocrinology and Metabolism·Muhammad Abdul-Ghani, Ralph A DeFronzo
Dec 12, 2007·Diabetes Care·Kenneth E HeikesLeonard Schlessinger
Jun 5, 2008·American Journal of Physiology. Endocrinology and Metabolism·Leigh PerreaultRobert H Eckel
Sep 9, 2008·Reviews in Endocrine & Metabolic Disorders·K J Chang-ChenE Bernal-Mizrachi

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Citations

Apr 3, 2014·Journal of Medical Internet Research·Penglai ChenDebin Wang
Apr 20, 2014·Current Diabetes Reports·Kristine FærchMarit Eika Jørgensen
Feb 14, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Guillermo De'MarzianiAlicia Elbert
Apr 26, 2019·The Diabetes Educator·Karen L RoperJames Keck
Nov 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Kristine FærchDorte Vistisen
Jan 15, 2020·Pharmaceutical Medicine·Amanda BergaminAlison M Hill
Jun 10, 2019·Diabetes Care·Katherine A PratteUNKNOWN Special Diabetes Program for Indians Diabetes Prevention Program
Oct 31, 2017·Journal of Diabetes Research·Matthias Ploug Larsen, Signe Sørensen Torekov
Dec 31, 2019·Current Diabetes Reviews·Georgios S Papaetis
May 29, 2021·Scientific Reports·Nita VangeepuramGaurav Pandey

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