Appropriate use of D-dimer in hospital patients

The American Journal of Medicine
Jecko ThachilCheng Hock Toh

Abstract

D-dimer, the final product of plasmin-mediated degradation of fibrin-rich thrombi, has emerged as a simple blood test that can be used in diagnostic algorithms for the exclusion of venous thromboembolism. D-dimer also is used as a part of the diagnostic tests for disseminated intravascular coagulation, where excessive thrombin generation is the key pathophysiological factor. However, there are no robust data available at present on the use of this test to exclude venous thromboembolism in a hospital inpatient. Considerable confusion also exists among physicians about its appropriate use and interpretation in disseminated intravascular coagulation. This article focuses on the available evidence to guide the appropriate use of D-dimer in patients admitted to a hospital.

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Citations

Mar 27, 2016·Laboratory Medicine·Roger S RileyRichard A McPherson
Feb 8, 2011·The American Journal of Cardiology·Avi ShimonyMark J Eisenberg
Oct 10, 2012·European Journal of Internal Medicine·Rachel HeathJecko Thachil
Jan 8, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jung Won LeeJae Il Shin
Jun 15, 2011·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Fang YinRobert Dobbin Chow
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Jan 21, 2011·American Journal of Therapeutics·Ranadeep MandhadiSerafin Chua
Feb 1, 2011·Continuum : Lifelong Learning in Neurology·Michael J Schneck, José Biller
Aug 25, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Karnrawee Kamolratanapiboon, Chaicharoen Tantanate
Apr 28, 2020·ANZ Journal of Surgery·Klaus Görlinger
Jul 15, 2020·The American Journal of Medicine·Christian H NickelMikkel Brabrand
May 25, 2020·Thrombosis Research·Fridtjof B RindeSigrid K Brækkan

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