Appropriate use of fluoroquinolones in children

International Journal of Antimicrobial Agents
Nicola Principi, Susanna Esposito

Abstract

With the increasing resistance to antibiotics among common bacterial pathogens, challenges associated with the use of fluoroquinolones (FQs) in paediatrics have emerged. The majority of FQs have favourable pharmacokinetic properties, although these properties can differ in children compared with adults. Moreover, all FQs have broad antimicrobial activity both against Gram-positive and Gram-negative bacteria. However, only some FQs for which adequate studies are available have been approved for use in children in a limited number of clinical situations owing to the supposed risk of development of severe musculoskeletal disorders, as demonstrated in juvenile animals. Recent short- and long-term evaluations appear to indicate that, at least for levofloxacin, this risk, if present at all, is marginal. This marginal risk could lead to more frequent use of FQs in children, even to treat diseases for which several other drugs with documented efficacy, safety and tolerability are considered the first-line antibiotics. However, for most of the FQs, adequate long-term studies of safety are not available. This indicates that the use of FQs should be limited to selected respiratory infections (including tuberculosis), exacerbation of lung ...Continue Reading

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Citations

Jun 24, 2015·Journal of Chemotherapy·Caterina BacciElena Chiappini
Jul 16, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Anicia M MedinaJoaquim Ruiz
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Nov 5, 2019·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Yanxiu GuoWansong Zong
Jul 16, 2019·Expert Opinion on Drug Safety·Nicola Principi, Susanna Esposito
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Dec 1, 2020·Molecular Informatics·Alexandre BorrelDenis Fourches
Feb 6, 2021·Expert Opinion on Pharmacotherapy·Susanna EspositoNicola Principi
Aug 18, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Georges AzarGeorges Caputo

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