Appropriateness of array-CGH in the ADHD clinics: A comparative study.

Genes, Brain, and Behavior
Marco BaccarinCarla Lintas

Abstract

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorder with a worldwide prevalence of about 5%. The disorder is characterized by inattentive, hyperactive and impulsive behavior and is often comorbid with other neuropsychiatric conditions. Array comparative genomic hybridization (array-CGH) testing has been proved to be useful to detect chromosomal aberrations in several neuropsychiatric conditions including autism spectrum disorders (ASD) and intellectual disability (ID). The usefulness of array-CGH in the ADHD clinics is still debated and no conclusive evidence has been reached to date. We performed array-CGH in 98 children and adolescents divided in two similarly sized groups according to the clinical diagnosis: (a) one group diagnosed with ADHD as primary diagnosis; (b) the other group in which ADHD was co-morbid with ASD and/or ID. We detected pathogenetic and likely pathogenetic copy number variants (CNVs) in 12% subjects in which ADHD was co-morbid with autism and/or intellectual disability and in 8.5% subjects diagnosed with ADHD as primary diagnosis. Detection of CNVs of unknown clinical significance was similar in the two groups being 27% and 32%, respectively. Benign and ...Continue Reading

References

Jun 1, 1978·Journal of Abnormal Child Psychology·C H GoyetteR F Ulrich
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Jun 24, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Ovsanna Tadevosyan-LeyferSusan E Folstein
Oct 24, 2003·Behavior Genetics·M J H RietveldD I Boomsma
Jun 14, 2005·Biological Psychiatry·Joseph Biederman
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
Dec 24, 2005·Journal of Attention Disorders·Stephen V Faraone, Joseph Biederman
Feb 18, 2010·The Psychiatric Clinics of North America·Stephen V Faraone, Eric Mick
Jul 27, 2010·Journal of Psychiatric Research·Joseph BiedermanStephen V Faraone
Aug 13, 2011·Science Translational Medicine·Anath C LionelStephen W Scherer
Feb 24, 2012·Neurochemical Research·Jing LuoGuojun Chen
Nov 1, 2013·Nucleic Acids Research·Jeffrey R MacDonaldStephen W Scherer
Nov 26, 2013·Journal of Psychiatric Research·Josep-Antoni Ramos-QuirogaMarta Ribasés
Jan 21, 2015·Molecular Psychiatry·Z HawiM A Bellgrove
Oct 28, 2015·Nature Reviews. Genetics·Lisenka E L M VissersJoris A Veltman
Sep 25, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Samuele Cortese
Nov 29, 2017·BMC Medical Genomics·Edna GrünblattSusanne Walitza
May 4, 2018·Psychiatry and Clinical Neurosciences·Oliver GrimmAndreas Reif
Jun 23, 2018·Frontiers in Psychiatry·Victoria Hayman, Thomas V Fernandez
Jul 23, 2019·Psychological Medicine·Anke R HammerschlagTinca J C Polderman

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