Appropriateness of empirical antibiotics: risk factors of adult patients with sepsis in the ICU.

International Journal of Clinical Pharmacy
Khalid Ahmad Al-SunaidarYahaya Prof Hassan

Abstract

Background The appropriateness of antibiotics is the basis for improving the survival of patients with sepsis. Objective This study aimed to determine the appropriateness of empirical antibiotics, reasons for non-appropriate empirical antibiotics, risk factors of mortality, length of stay in intensive care unit (ICU-LOS) and Acute Physiology And Chronic Health Evaluation II (APACHE II) score predictors in adult patients with sepsis. Setting An adult ICU of a tertiary hospital in  Malaysia. Methods A retrospective cohort study was conducted amongst patients with sepsis. Data were retrieved from the patients' files and computer system. Each case was reviewed for the appropriateness of empirical antibiotics based on ICU local guidelines, bacterial sensitivity, dose, frequency, creatinine clearance and time of administration of empirical antibiotics. Multivariable logistic and Cox regression modelling were performed to compute the adjusted association of receiving appropriate or inappropriate empirical antibiotics with ICU mortality. Multivariable linear regression modelling was performed using ICU-LOS and APACHE II scores. Main outcome measures were ICU mortality, severity score (APACHE II scores) and ICU-LOS. Results The total mo...Continue Reading

References

Dec 24, 2005·Critical Care Medicine·Greg S MartinMarc Moss
Oct 19, 2011·Antimicrobial Agents and Chemotherapy·Pilar RetamarUNKNOWN SAEI/SAMPAC Bacteremia Group
Dec 30, 2011·The American Journal of Emergency Medicine·Ching-Chi LeeWen-Chien Ko
Jun 19, 2012·Médecine et maladies infectieuses·T LeventM Vasseur
Dec 25, 2012·The Journal of Emergency Medicine·Brian M FullerCraig McCammon
Dec 18, 2013·Virulence·Florian B MayrDerek C Angus
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Marjorie BeumierFabio Silvio Taccone
Sep 17, 2014·PloS One·Jianfang ZhouUNKNOWN China Critical Care Clinical Trials Group
Feb 24, 2015·Alimentary Pharmacology & Therapeutics·C J KarvellasUNKNOWN Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group
Apr 22, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J BoelM Arpi
Dec 18, 2015·Hospital Practice·Sophia M CardwellMichael D Nailor
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Lonneke A van VughtUNKNOWN MARS Consortium
Apr 8, 2016·Critical Care : the Official Journal of the Critical Care Forum·Philippe MontraversJean Guglielminotti
Dec 3, 2016·Emergency Medicine Clinics of North America·Michael G AllisonBryan D Hayes
Jan 19, 2017·Critical Care Medicine·Andrew RhodesR Phillip Dellinger
Jan 26, 2017·The British Journal of Surgery·J-L Vincent
Feb 16, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Pradeep KumarA S Arunkumar
Mar 16, 2017·Nursing in Critical Care·Elizabeth PapathanassoglouKathleen Hegadoren
Feb 27, 2019·Chinese Medical Journal·Xiang ZhouYun Long
May 22, 2019·American Journal of Infection Control·DaleMarie VaughanShaina Bernard

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.