Appropriateness of psychotropic medication use in a cohort of adolescents with intellectual disability in Queensland, Australia

BJPsych Open
M SongD Harley

Abstract

Psychotropic medications are sometimes used off-label and inappropriately. This may cause harm to adolescents with intellectual disability. However, few studies have analysed off-label or inappropriate prescribing to this group. To examine the appropriateness of psychotropic prescribing to adolescents with intellectual disability living in the community in south-east Queensland, Australia. Off-label medication use was determined based on whether the recorded medical condition treated was approved by the Australian Therapeutic Goods Administration. Clinical appropriateness of medication use was determined based on published guidelines and clinical opinion of two authors who specialise in developmental disability medicine (J.N.T. and D.H.). We followed 429 adolescents for a median of 4.2 years. A total of 107 participants (24.9%) were prescribed psychotropic medications on at least one occasion. Of these, 88 (82.2%) were prescribed their medication off-label or inappropriately at least once. Off-label or inappropriate use were most commonly associated with challenging behaviours. Off-label or inappropriate use of psychotropic medications was common, especially for the management of challenging behaviours. Clinical decision-making...Continue Reading

References

Oct 7, 2005·Journal of Intellectual Disability Research : JIDR·C Haw, J Stubbs
Dec 22, 2006·American Journal of Mental Retardation : AJMR·John R TaffeBruce J Tonge
Jun 29, 2010·Research in Developmental Disabilities·Johnny L Matson, Sara Mahan
Aug 10, 2013·Pharmacoepidemiology and Drug Safety·Tan DoanNicholas Lennox
Feb 13, 2016·Journal of Applied Research in Intellectual Disabilities : JARID·Lyn McPhersonNicholas Lennox
Jun 28, 2016·Developmental Medicine and Child Neurology·Nicholas LennoxRobert S Ware
Oct 21, 2016·Australian Prescriber·Julian N TrollorCatherine Franklin
Jun 1, 2017·Journal of Intellectual Disability Research : JIDR·G M de Kuijper, P J Hoekstra
Aug 20, 2017·BMJ : British Medical Journal·Rory SheehanAngela Hassiotis
Sep 29, 2018·Journal of Applied Research in Intellectual Disabilities : JARID·Gerda M de Kuijper, Pieter J Hoekstra
Feb 23, 2019·Journal of Applied Research in Intellectual Disabilities : JARID·Bas KleijwegtBerno van Meijel

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