Approved and investigational uses of modafinil : an evidence-based review.

Drugs
Raminder Kumar

Abstract

Modafinil is a wake-promoting agent that is pharmacologically different from other stimulants. It has been investigated in healthy volunteers, and in individuals with clinical disorders associated with excessive sleepiness, fatigue, impaired cognition and other symptoms. This review examines the use of modafinil in clinical practice based on the results of randomized, double-blind, placebo-controlled clinical trials available in the English language in the MEDLINE database. In sleep-deprived individuals, modafinil improves mood, fatigue, sleepiness and cognition to a similar extent as caffeine but has a longer duration of action. Evidence for improved cognition in non-sleep-deprived healthy volunteers is controversial.Modafinil improves excessive sleepiness and illness severity in all three disorders for which it has been approved by the US FDA, i.e. narcolepsy, shift-work sleep disorder and obstructive sleep apnoea with residual excessive sleepiness despite optimal use of continuous positive airway pressure (CPAP). However, its effects on safety on the job and on morbidities associated with these disorders have not been ascertained. Continued use of CPAP in obstructive sleep apnoea is essential. Modafinil does not benefit cata...Continue Reading

References

Aug 8, 1979·Psychopharmacology·G M SimpsonG Gardos
Jul 1, 1976·Journal of Clinical Psychology·C J Golden
Jan 1, 1988·Psychopharmacology·J MassolP Simon
May 1, 1986·Psychiatry Research·A J RushC Burns
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen
Dec 1, 1993·Drug and Alcohol Dependence·S T TiffanyJ E Henningfield
May 1, 1996·Sleep·J J Pilcher, A I Huffcutt
Feb 1, 1997·Archives of General Psychiatry·J M GoldD R Weinberger
Feb 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H CallicottD R Weinberger
Mar 11, 1998·Journal of Sleep Research·J CarrierD J Kupfer
Aug 12, 1998·Addictive Behaviors·K M KampmanL E Epperson
Aug 13, 1998·Journal of Abnormal Child Psychology·C K ConnersJ N Epstein
Oct 26, 1999·Development and Psychopathology·B CornblattL Erlenmeyer-Kimling
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A I PackJ K Matheson
Feb 2, 2002·Clinical Pharmacology and Therapeutics·Philmore RobertsonMichael Nelson
Feb 8, 2002·Journal of Clinical Pharmacology·Philmore RobertsonMichael Nelson
Feb 28, 2002·Psychopharmacology·Nancy Jo WesenstenThomas J Balkin
Mar 7, 2002·Archives of General Psychiatry·Rajesh NarendranCynthia A Pristach

❮ Previous
Next ❯

Citations

Jul 1, 2009·Der Nervenarzt·H Förstl
Mar 4, 2009·Psychopharmacology·Ralf RegenthalUte Krügel
Sep 29, 2011·Psychopharmacology·Mohammad ArbabiShahin Akhondzadeh
Aug 31, 2011·Current Psychiatry Reports·Marsal Sanches, Jair C Soares
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessandro GozziMarina Bentivoglio
Apr 2, 2009·Nature Reviews. Rheumatology·Chad S Boomershine, Leslie J Crofford
Jan 1, 2011·BMJ Case Reports·Swaroop Revannasiddaiah, Tapesh Bhattacharyya
Jan 1, 2011·BMJ Case Reports·Einstein Francisco Camargos, Juliana Lima Quintas
Aug 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Chad S Boomershine
Jun 27, 2009·Neuropsychiatric Disease and Treatment·Donald E GreydanusDilip R Patel
Feb 18, 2011·CNS Drugs·Bettina KnieK Ray Chaudhuri
Dec 18, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elizabeth HoveyUNKNOWN MOTIF investigators
Oct 29, 2013·Multiple Sclerosis International·David J LevinthalKlaus Bielefeldt
Oct 15, 2013·Drugs·Alberto K De la Herrán-Arita, Fabio García-García
Mar 1, 2012·Environmental Health and Toxicology·Dongsoo Kim
Sep 1, 2011·Organic & Biomolecular Chemistry·Viktor MojrTomáš Kraus
Apr 23, 2011·Expert Opinion on Investigational Drugs·Niels PlathJohn Paul Redrobe
Mar 27, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Andrew I GellerDale C Strasser
Nov 16, 2010·Journal of Pain and Symptom Management·Paul HowardAndrew Wilcock
Feb 23, 2010·Journal of Psychiatric Research·J BeckE Holsboer-Trachsler
Oct 20, 2009·Child and Adolescent Psychiatric Clinics of North America·Suresh Kotagal
Dec 15, 2015·Journal of Clinical Psychopharmacology·Claire C ConleyOxana G Palesh
Aug 6, 2009·Progress in Neurobiology·Mortimer Mamelak
Sep 15, 2009·Pharmacology, Biochemistry, and Behavior·Javier Franco-Pérez, Carlos Paz
Apr 25, 2009·Physical Medicine and Rehabilitation Clinics of North America·John C Pan, David N Bressler
Jan 9, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Kirstie AndersonJulia L Newton
Feb 28, 2013·Internal Medicine Journal·S GeffenH M Tan
Aug 19, 2011·Journal of Sleep Research·Hal A Droogleever FortuynGijs Bleijenberg
Mar 6, 2010·Annals of the New York Academy of Sciences·Heath D Schmidt, R Christopher Pierce
Sep 19, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R M Battleday, A-K Brem
Apr 20, 2016·Current Treatment Options in Neurology·Divyanshu DubeyOlaf Stüve
May 6, 2016·Frontiers in Psychology·Pavel DietzAndreas G Franke
Mar 31, 2015·Frontiers in Neurology·Ekaterina DobryakovaGlenn R Wylie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.