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Nonparametric inference of the distribution of fitness effects across functional categories in humans

bioRxiv

Feb 4, 2014

Fernando Racimo, Joshua G Schraiber

Abstract

Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DF...read more

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CTCF gene
Site
Silent Mutation
European Race
Na-deacetyl-ferrocenoyl-strychnobrasiline
Mutation Abnormality
Nucleotides
Genetic Polymorphism
Negative Selection
Shapes
14
3
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Nonparametric inference of the distribution of fitness effects across functional categories in humans

bioRxiv

Feb 4, 2014

Fernando Racimo, Joshua G Schraiber

PMID: 990002345

DOI: 10.1101/002345

Abstract

Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DF...read more

Mentioned in this Paper

CTCF gene
Site
Silent Mutation
European Race
Na-deacetyl-ferrocenoyl-strychnobrasiline
Mutation Abnormality
Nucleotides
Genetic Polymorphism
Negative Selection
Shapes
14
3

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