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Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms

bioRxiv

Feb 4, 2014

Fernando Racimo, Joshua G. Schraiber

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Abstract

Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DF...read more

Mentioned in this Paper

Gene Polymorphism
Silent Mutation
Diffusion Weighted Imaging
Single Nucleotide Polymorphism
Genetic Polymorphism
Mutation Abnormality
Genome
CTCF gene
Site
Fitting - Action
14
3
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  • Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms

    bioRxiv

    Feb 4, 2014

    Fernando Racimo, Joshua G. Schraiber

    PMID: 990002345

    DOI: 10.1101/002345

    Abstract

    Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DF...read more

    Mentioned in this Paper

    Gene Polymorphism
    Silent Mutation
    Diffusion Weighted Imaging
    Single Nucleotide Polymorphism
    Genetic Polymorphism
    14
    3

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