Apraxia profiles-A single cognitive marker to discriminate all variants of frontotemporal lobar degeneration and Alzheimer's disease

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Andreas JohnenThomas Duning

Abstract

Apraxia is common in neurodegenerative dementias but underrepresented in clinical workup for differential diagnoses. Praxis-profiles were assessed with the Dementia Apraxia Test in 93 patients with early stages of biologically supported Alzheimer's disease or frontotemporal lobar degeneration: semantic primary-progressive aphasia, nonfluent primary-progressive aphasia, and behavioral variant frontotemporal dementia. Associations with core cognitive deficits of the dementia subtypes (i.e., visuospatial, sociocognitive, and semantic-linguistic) were explored. Patients showed significant apraxia compared with healthy controls but also disease-specific praxis-profiles. Using only the Dementia Apraxia Test, all four dementia subtypes could be correctly discriminated in 64.4% of cases, and in 78.2% when only distinguishing Alzheimer's disease versus frontotemporal lobar degeneration. Praxis-profiles showed consistent associations with core cognitive impairments of the different dementia subtypes. The Dementia Apraxia Test is a valid, time-efficient and versatile cognitive marker to delineate variants of frontotemporal lobar degeneration and Alzheimer's disease in clinical routine, facilitating differential diagnoses of dementia subty...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1993·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·K Handeland, A Skorping
Feb 1, 1997·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A KerteszH Fox
Mar 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·A D Hutchinson, J L Mathias
Jan 2, 2008·American Journal of Alzheimer's Disease and Other Dementias·Jason E OsherSandra Weintraub
Nov 13, 2009·Journal of Neurology·Jonathan Daniel RohrerJason D Warren
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Apr 14, 2011·Stroke; a Journal of Cerebral Circulation·Constance Flamand-RozeChristian Denier
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Feb 1, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Maxime BertouxMarie Sarazin
May 11, 2012·Neurology·S A SajjadiP J Nestor
Aug 15, 2012·Brain and Language·Ferdinand Binkofski, Laurel J Buxbaum
Jan 30, 2013·Journal of Neurology·Anahita AdeliKeith A Josephs
Feb 5, 2013·Applied Neuropsychology. Adult·Nora Silvana ViglieccaMarcelo Rinaldo Vigliecca
Apr 2, 2013·Journal of Alzheimer's Disease : JAD·Leonardo Cruz de SouzaMarie Sarazin
May 8, 2013·Journal of Neurology·Thomas BenkeMargarete Delazer
Aug 2, 2013·Neuropsychology Review·Mathieu LesourdFrançois Osiurak
Apr 30, 2014·Brain : a Journal of Neurology·Laurel J BuxbaumH Branch Coslett
Jul 16, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jennifer M HarrisMatthew Jones
Jul 27, 2014·Brain : a Journal of Neurology·Markus HoerenCornelius Weiller
Sep 25, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Andreas JohnenHubertus Lohmann
Jan 8, 2016·Dementia and Geriatric Cognitive Disorders·Shunichiro ShinagawaKatherine P Rankin
May 11, 2016·Dementia and Geriatric Cognitive Disorders·Everard G B VijverbergYolande A L Pijnenburg
Jun 3, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Samrah AhmedChristopher R Butler
Aug 10, 2016·Journal of Neurochemistry·Elizabeth GordonNick C Fox
Oct 27, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Andreas JohnenThomas Duning
Oct 19, 2016·Journal of the International Neuropsychological Society : JINS·Siddharth RamananMichael Hornberger
Jul 5, 2017·Neuroscience Letters·Antonio Del CasalePaolo Girardi

❮ Previous
Next ❯

Citations

Aug 24, 2019·Journal of the American Geriatrics Society·Qu TianStephanie A Studenski
Aug 19, 2020·American Journal of Speech-language Pathology·Jara StalpaertMiet De Letter
May 19, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Aino Yliranta, Mervi Jehkonen
Sep 3, 2021·Acta neurologica Belgica·Georgios PapadopoulosPanagiotis Ioannidis

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

© 2022 Meta ULC. All rights reserved