Apremilast: A Novel Drug for Treatment of Psoriasis and Psoriatic Arthritis

The Annals of Pharmacotherapy
Stacy L HaberEvelyn Pierce

Abstract

To review the pharmacology, efficacy, and safety of apremilast and determine its role relative to other agents in the treatment of psoriasis and psoriatic arthritis. A PubMed search (1946 to December 2015) using the terms apremilast and CC-10004 was conducted to identify relevant articles. In vitro or in vivo evaluations of apremilast published in the English language were eligible for inclusion. Controlled clinical trials that involved psoriasis or psoriatic arthritis were selected for review. Four trials were identified on the treatment of psoriasis. In those that involved doses of 30 mg twice daily, a significantly greater percentage of patients receiving apremilast (28.8% to 40.9%) compared with placebo (5.3% to 5.8%) achieved at least 75% improvement from baseline in Psoriasis Area and Severity Index score at 16 weeks. Two trials were identified on the treatment of psoriatic arthritis. In the one that involved a dose of 30 mg twice daily, a significantly greater percentage of patients receiving apremilast (38.1%) compared with placebo (19.0%) achieved the American College of Rheumatology criteria for 20% improvement at 16 weeks. In all trials, the drug had an acceptable safety profile, with the most common adverse effects ...Continue Reading

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Citations

Apr 27, 2017·Expert Opinion on Drug Safety·A López-FerrerL Puig
Mar 21, 2017·Clinical Pharmacology and Therapeutics·J G TurbevilleS R Feldman
Feb 19, 2017·Drugs·Gillian M Keating
Feb 19, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sergio Camilo Lopez-GarciaDetlef Bockenhauer
Apr 9, 2019·The Journal of Dermatology·Sari OkazakiShigetoshi Sano
Dec 1, 2017·Expert Opinion on Investigational Drugs·Peter Theut RiisGregor B Jemec

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