Apremilast in the Management of Disseminated Granuloma Annulare.

Curēus
Tejas P Joshi, Jaime Tschen

Abstract

Granuloma annulare (GA) is a common inflammatory skin condition that manifests as annular skin colored to erythematous papules and plaques. Disseminated GA is a subtype of GA that presents with diffuse cutaneous involvement. While topical and intralesional corticosteroids and phototherapy have been used as therapies for GA, there is no consensus on the best course of treatment for GA. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that has been Food and Drug Administration (FDA) approved for psoriasis, psoriatic arthritis, and oral ulcers associated with Behcet's disease; apremilast has also shown promise off-label for other inflammatory skin conditions. Here, we present the case of a woman in whom apremilast use led to an almost complete resolution of her disseminated GA. Our patient tolerated apremilast well and reported no side effects. We also review the literature on the use of apremilast in other patients with GA.

References

May 23, 2013·American Journal of Clinical Dermatology·Laura A Thornsberry, Joseph C English
Feb 5, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·J LukácsP Elsner
Feb 19, 2017·Drugs·Gillian M Keating
Dec 13, 2017·American Journal of Clinical Dermatology·Jenny Wang, Amor Khachemoune
Apr 3, 2019·The Journal of Dermatological Treatment·Nolan J MaloneyKyle Cheng
Aug 23, 2019·JAMA Dermatology·Anuradha BishnoiSunil Dogra
Nov 26, 2019·JAAD Case Reports·Stacy Blum, David Altman
Mar 24, 2021·Journal of the American Academy of Dermatology·Matthew L HrinWilliam W Huang

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