Aprepitant versus metoclopramide, both combined with dexamethasone, for the prevention of cisplatin-induced delayed emesis: a randomized, double-blind study

Annals of Oncology : Official Journal of the European Society for Medical Oncology
F RoilaF Zerilli

Abstract

A combination of aprepitant, a 5-HT3 receptor antagonist (r.a.), and dexamethasone is recommended for the prophylaxis of cisplatin-induced nausea and vomiting in the acute phase, and aprepitant + dexamethasone (A + D) in the delayed phase. The aim of this study was to verify if A + D is superior to metoclopramide plus dexamethasone (M + D) in preventing delayed emesis in cancer patients receiving the same prophylaxis for acute emesis. A randomized double-blind study comparing A + D versus M + D was completed in previously untreated cancer patients. Before chemotherapy, all patients were treated with intravenous palonosetron 0.25 mg and dexamethasone 12 mg, and oral aprepitant 125 mg. On day 2-4, patients randomly received oral dexamethasone 8 mg plus aprepitant 80 mg once daily (days 2-3) or metoclopramide 20 mg four times daily plus dexamethasone 8 mg bid. Primary endpoint was rate of complete response (no vomiting, no rescue treatment) in day 2-5 after chemotherapy. Due to difficulty in the accrual of patients, 303 of the 480 planned patients were enrolled, 284 were fully evaluable, 147 receiving A + D, 137 M + D. Day 1 results were similar in both arms. On day 2-5, complete response rate was not significantly different (80.3...Continue Reading

References

Oct 1, 1992·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·C M LindleyJ T Osterhaus
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G WarrFranck Skobieranda
Nov 30, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F RoilaUNKNOWN Antiemetic Subcommitte of the Multinational Association of Supportive Care in Cancer
Mar 10, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollC Y Chan
Sep 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ethan BaschUNKNOWN American Society of Clinical Oncology

❮ Previous
Next ❯

Citations

Dec 24, 2015·Current Oncology Reports·Thomas K H LauWinnie Yeo
Sep 25, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F RoilaUNKNOWN participants of the MASCC/ESMO Consensus Conference Copenhagen 2015
Aug 2, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J HeskethGary H Lyman
Feb 3, 2016·The Cochrane Database of Systematic Reviews·Robert S PhillipsBarry Pizer
Mar 21, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jin Hyoung KangHwa Jung Kim
Oct 5, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yasmeen RazviKatarzyna Joanna Jerzak
Jul 23, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jørn HerrstedtMatti S Aapro
Mar 16, 2016·Journal of Global Oncology·Bishal GyawaliMahesh Iddawela
Jan 22, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Snežana M BošnjakLee Schwartzberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
F RoilaMaurizio Tonato
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
David G WarrK J Horgan
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
A R MartinS M Grunberg
© 2022 Meta ULC. All rights reserved