APRIL in B-cell malignancies and autoimmunity

Results and Problems in Cell Differentiation
Fiona C KimberleyMichael Hahne

Abstract

A Proliferation Inducing Ligand (APRIL) was first identified as a cytokine expressed predominantly by tumour tissues and was not found in most normal tissues. The activity of this new cytokine, in terms of its ability to stimulate tumour cell proliferation in vivo, determined the catchy acronym of yet another TNF family cytokine: APRIL. Reports showing an association between APRIL and cancer have since been prolific, in particular, those showing a link with B cell malignancies. Evidence is accumulating that APRIL is also a player in several autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and Sjoegren's syndrome. However, we now know that APRIL also plays an important role in the immune system and in lymphocyte biology. In this chapter we outline the physiological role of APRIL in immunity and describe what is known regarding the role of APRIL in B cell malignancies and autoimmune disease.

Citations

Jun 19, 2012·Cell Death and Differentiation·V LascanoM Hahne
Sep 11, 2012·The Journal of Biological Chemistry·Fiona C KimberleyJan Paul Medema
Dec 31, 2010·Journal of Virology·Timothy W PharesCornelia C Bergmann
May 22, 2013·Journal of Thyroid Research·Francis S BalucanTerry F Davies
Apr 27, 2018·Journal of Pediatric Hematology/oncology·Baolan SunYoujia Wu
Oct 5, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Matthias A NeusserClemens D Cohen
Nov 28, 2012·Annals of the Rheumatic Diseases·Leticia FernandezMichael Hahne
Aug 1, 2020·Journal of Clinical Medicine·Roberto TammaDomenico Ribatti

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