PMID: 9527194Apr 4, 1998Paper

Aprotinin and dipyridamole for the safe reduction of postoperative blood loss

The Annals of Thoracic Surgery
G CohenD A Mickle

Abstract

Aprotinin (APR) reduces postoperative blood loss but may induce thrombosis. Dipyridamole (DIP) limits platelet aggregation and may reduce the thrombotic complications associated with APR. To evaluate the safety and effectiveness of combined APR and DIP, we undertook a prospective randomized trial in patients undergoing cardiac operations. Patients were stratified according to risk for bleeding (low or high), and received either DIP with placebo (DIP group; n = 59) or DIP with APR (DIP + APR group; n = 56). Blood samples were obtained for the measurement of hematologic and biochemical parameters. Blood loss and transfusion requirements were documented postoperatively. Postoperative blood loss and transfusion requirements were significantly lower in the DIP + APR group at 6, 12, and 24 hours after bypass (p < 0.01). No significant differences were found between groups in the incidence of perioperative mortality (DIP, 0%; DIP + APR, 3%), myocardial infarction (DIP, 0%; DIP + APR, 3%), stroke (DIP, 1%; DIP + APR, 1%), or potential thrombotic events (death, myocardial infarction, and stroke: DIP, 2%; DIP + APR, 5%). In addition, these rates did not differ from those of nonparticipating matched control patients. Administration of bot...Continue Reading

References

Dec 1, 1992·The Annals of Thoracic Surgery·D M CosgroveF D Loop
Dec 1, 1987·The Annals of Thoracic Surgery·W van OeverenC R Wildevuur
Jan 1, 1989·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·C R WildevuurW van Oeveren
Jan 1, 1987·Seminars in Thrombosis and Hemostasis·C KluftJ J Emeis
Jan 1, 1987·Annals of the New York Academy of Sciences·R W ColmanL H Edmunds
May 29, 1986·The New England Journal of Medicine·L A Harker
Sep 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·J M KarskiM F Glynn
Apr 1, 1993·The Annals of Thoracic Surgery·S Westaby
Jan 1, 1993·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S E FremesB S Goldman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.