PMID: 8604927Dec 1, 1995Paper

Aprotinin in children undergoing repair of congenital heart defects

The Annals of Thoracic Surgery
P PenkoskeW Gibb

Abstract

Aprotinin use in adults is increasing, and its use in children has recently been reported. The efficacy of aprotinin in children was tested in 80 children. Patients were in four groups: reoperations (59), neonates (8), extremely cyanotic children (6), and other complex repairs (7). The results were compared with those of 55 control infants and children: reoperations (25), neonates (10), cyanotic (10) and complex (10). Treatment groups were identical in age, sex ratio, cross-clamp time, and bypass time. Patients treated with aprotinin had a significant reduction in chest tube drainage (16.5 +/- 9.8 versus 33.4 +/- 22.1 mL.kg-1.h-1; p < 0.001) and time to skin closure (64.2 +/- 23.7 versus 80.1 +/- 24.6 minutes; p < 0.001). Transfusion requirements were decreased in aprotinin-treated patients 4.2 +/- 3.4 versus 6.7 +/- 5.2 donors; p < 0.001). All of the control patients were exposed to at least one donor, whereas 10/80 (12.5%) of the aprotinin-treated group had no blood use (p < 0.006). There were no cases of renal insufficiency or allergic reactions in children receiving aprotinin. Three patients had thrombotic episodes: 2 superior vena caval problems and a lower extremity deep venous thrombosis. There were 3 cases of mediastini...Continue Reading

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Citations

Apr 10, 2003·The Annals of Thoracic Surgery·John M CostelloConstantine Mavroudis
Mar 21, 2000·Transfusion Science·J L Kwiatkowski, C S Manno
Jan 27, 2006·The New England Journal of Medicine·Dennis T ManganoUNKNOWN Ischemia Research and Education Foundation
Jul 1, 1998·The Annals of Thoracic Surgery·H Mössinger, W Dietrich
Jan 6, 2000·Journal of Cardiothoracic and Vascular Anesthesia·G D Williams, C Ramamoorthy
Apr 10, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Michael P Eaton, George M Alfieris
Nov 1, 1996·The Annals of Thoracic Surgery·J S TweddellS B Litwin
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P P PunjabiK M Taylor
Jul 1, 1998·The Annals of Thoracic Surgery·P Pouard
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·William C OliverFrancisco J Puga
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Emad B MossadJohn Apostolakis
May 16, 2000·Critical Care Medicine·J Amato
Mar 20, 2008·Anesthesia and Analgesia·Michael P Eaton
Feb 16, 2006·Journal of Korean Medical Science·Tae-Jin Yun, Joon-Ryang Rho
Dec 1, 1996·Anesthesia and Analgesia·C C D'ErricoE L Bove
Aug 21, 2008·Anesthesia and Analgesia·Chinnamuthu MurugesanKanchi Muralidhar
Mar 10, 2001·The Annals of Thoracic Surgery·R P Scott

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