Aprotinin in the management of Achilles tendinopathy: a randomised controlled trial

British Journal of Sports Medicine
R BrownG Nalder

Abstract

Achilles tendinopathy is a common condition, which can become chronic and interfere with athletic performance. The proteinase inhibitor aprotinin (as injection) has been found to improve recovery in patellar tendinopathy (evidence level 1b) and Achilles tendinopathy. Internationally this therapy is being used based on this limited knowledge base. To evaluate whether aprotinin injections decrease time to recovery in Achilles tendinopathy. A prospective, randomised, double blind, placebo controlled trial was performed comparing saline (0.9%) plus local anaesthetic injections and eccentric exercises with aprotinin (30,000 kIU) plus local anaesthetic injection and eccentric exercise. Three injections were given, each a week apart. In total, 26 patients, with 33 affected tendons, were enrolled for this study. At no follow up point (2, 4, 12, or 52 weeks) was there any statistically significant difference between the treatment group and placebo. This included VISA-A scores and secondary outcome measures. However, a trend for improvement over placebo was noted. In this study on Achilles tendinopathy, aprotinin was not shown to offer any statistically significant benefit over placebo. Larger multicentre trials are needed to evaluate th...Continue Reading

References

Dec 1, 1992·Acta Orthopaedica Scandinavica·M Aström, N Westlin
Oct 1, 1986·Journal of the American Podiatric Medical Association·S I Subotnick, P Sisney
Nov 1, 1984·The American Journal of Sports Medicine·A LowdonA G Mowat
Oct 1, 1996·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·I ShrierH W Kohl
Jun 23, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·D IrelandG Riley
Oct 2, 2001·British Journal of Sports Medicine·J M RobinsonUNKNOWN Victorian Institute Of Sport Tendon Study Group
Jun 11, 2002·British Journal of Sports Medicine·Mika PaavolaM Järvinen
Jan 30, 2003·Acta Orthopaedica Scandinavica·Sai C FuChrister G Rolf
Sep 9, 2004·Medicine and Science in Sports and Exercise·Nicola MaffulliJohn B King
Feb 3, 2005·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Håkan Alfredson, Lars Ohberg

❮ Previous
Next ❯

Citations

Feb 2, 2010·Skeletal Radiology·Nevin T WijesekeraJeremiah C Healy
Aug 19, 2011·Skeletal Radiology·Daniel I Rosenthal
Feb 6, 2008·Photomedicine and Laser Surgery·Steve TumiltyG David Baxter
Mar 4, 2010·British Medical Bulletin·R J de VosN Maffulli
Aug 9, 2011·Sports Medicine and Arthroscopy Review·Raffaele GarofaloAlessandro Castagna
Jan 7, 2009·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Robert A MagnussenA Brian Thomson
Jul 1, 2009·Sports Health·Christopher Kaeding, Thomas M Best
Oct 27, 2009·Journal of Foot and Ankle Research·Shannon E MunteanuLisa A Scott
Jun 15, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alex ScottKarim Khan
Sep 2, 2010·The Journal of Orthopaedic and Sports Physical Therapy·Christopher R CarciaUNKNOWN Orthopaedic Section of the American Physical Therapy Association
Feb 4, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·M N van Sterkenburg, C N van Dijk
Apr 17, 2014·British Medical Bulletin·Antonio FrizzieroNicola Maffulli
Nov 5, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Ruben ZwiersC Niek van Dijk
May 4, 2012·The British Journal of Radiology·R S D Campbell, A J Dunn
Jun 24, 2010·Expert Opinion on Pharmacotherapy·Nicola MaffulliVincenzo Denaro
Jul 9, 2008·Disability and Rehabilitation·Jan D RompeNicola Maffulli
Apr 4, 2013·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Anne-Marie HutchisonDavid Beard
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Angelo Del BuonoNicola Maffulli
Dec 10, 2015·Scandinavian Journal of Medicine & Science in Sports·J V IversenH Langberg
Aug 19, 2007·Journal of Science and Medicine in Sport·John OrchardRichard Brown
Sep 22, 2015·The Journal of Orthopaedic and Sports Physical Therapy·Karin Grävare Silbernagel, Kay M Crossley
Jul 16, 2009·Scandinavian Journal of Medicine & Science in Sports·A MeyerG D Baxter
Aug 18, 2006·Journal of Science and Medicine in Sport·Nicholas J Rukin, Nicola Maffulli
Aug 20, 2015·The Indian Journal of Radiology & Imaging·Aditya Ravindra Daftary, Alpana Sudhir Karnik
Oct 28, 2009·Foot and Ankle Clinics·Jason E Lake, Susan N Ishikawa
May 3, 2013·Foot & Ankle International·Christopher E GrossGeorge B Holmes
Mar 25, 2008·The American Journal of Sports Medicine·Timothy P C KaneJames D F Calder
Nov 17, 2009·Foot & Ankle International·Xan F CourvillePaul J Hecht
Feb 4, 2009·The American Journal of Sports Medicine·Jonathan D ReesJill Cook
May 27, 2015·The Cochrane Database of Systematic Reviews·Rebecca S KearneyMatthew L Costa
May 2, 2008·Clinical Orthopaedics and Related Research·John OrchardJamie Hofmann
Aug 15, 2009·Sports Medicine and Arthroscopy Review·Mohammad Saqib ZafarNicola Maffulli
Aug 29, 2006·Current Sports Medicine Reports·Alexander Scott, Maureen C Ashe
May 1, 2020·Foot & Ankle International·Ian JarinJ Turner Vosseller
Sep 30, 2014·JBJS Reviews·Nicola MaffulliAngelo Del Buono
Nov 26, 2016·BioMed Research International·Hong-Yun Li, Ying-Hui Hua
Sep 27, 2020·International Journal of Molecular Sciences·Christelle Darrieutort-LaffiteBenoit Le Goff
Dec 15, 2020·BMJ : British Medical Journal·Arco C van der VlistRobert-Jan de Vos
Nov 13, 2007·Foot and Ankle Clinics·Michael S HennessySimon W Sturdee
Oct 26, 2021·PeerJ·Wesley MatthewsWayne A Hing

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.