PMID: 7524460Oct 1, 1994Paper

Aprotinin preserves hemostasis in aspirin-treated patients undergoing cardiopulmonary bypass

The Annals of Thoracic Surgery
N TabuchiC R Wildevuur

Abstract

Various clinical trials have shown that hemostasis is improved by the administration of aprotinin during cardiopulmonary bypass. However, this effect has not been proved for those patients treated preoperatively with aspirin. Therefore, a double-blind, placebo-controlled study was conducted to test the efficacy of low-dose aprotinin (2 x 10(6) KIU in the pump prime solution) in preserving hemostasis in 40 aspirin-treated (325 mg) patients undergoing coronary artery bypass grafting. Aprotinin brought about a decrease in the postoperative blood loss (p < 0.05). The in vitro bleeding test (Thrombostat) demonstrated that aprotinin preserved the platelet hemostatic function in aspirin-treated patients during cardiopulmonary bypass (p < 0.05). The inhibitory effects of aspirin on collagen-induced platelet aggregation and thromboxane production were not influenced by aprotinin treatment. The findings from the present study indicate that aprotinin preserves hemostasis in aspirin-treated patients during cardiopulmonary bypass, but aspirin's effect on platelets is maintained. Therefore, aprotinin seems to be a useful adjunct treatment in aspirin-treated patients undergoing coronary artery bypass grafting.

Citations

Feb 1, 1995·The Annals of Thoracic Surgery·R G SpeekenbrinkL Eijsman
Dec 9, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·M KleinE Gams
May 30, 2002·Annals of Surgery·Victor A FerrarisRobert M Mentzer
Jan 1, 1997·The Annals of Thoracic Surgery·C BaufretonD Y Loisance
Mar 25, 2009·Expert Opinion on Drug Safety·Alexander KulikMarc Ruel
Jan 9, 1999·Perfusion·J A HydeT R Graham
Nov 11, 2005·Clinical Trials : Journal of the Society for Clinical Trials·Dean FergussonStan Shapiro
Nov 8, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Robert H ThieleMitchell H Rosner
Mar 1, 1997·European Journal of Anaesthesiology. Supplement·P A Flordal
Sep 4, 1999·Anesthesia and Analgesia·S C KettnerM Zimpfer
Apr 1, 1996·The Annals of Pharmacotherapy·S RobertM Richer

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