Aprotinin reduces the need for blood products during liver transplantation

American Journal of Surgery
C H ScudamoreS R Erb

Abstract

Bleeding complications and blood product consumption have been a major concern during liver transplantation. Prevention of plasminogen activation and fibrinolysis by aprotinin administration has been shown to reduce perioperative bleeding during operations associated with high blood-product consumption. Use of blood-products (packed red cells, frozen plasma, platelets, and cryoprecipitate) was analyzed both during the three stages of orthotopic liver transplantation and during total hospitalization of the 26 patients transplanted without aprotinin and the subsequent 40 patients with aprotinin. A similar analysis was performed for 15 patients immediately before and after the introduction of aprotinin to eliminate the "learning curve" effect for liver transplantation. The effect of epsilon-amino-caproic acid was analyzed as 13 patients received neither epsilon-aminocaproic acid nor aprotinin and 13 patients received epsilon-aminocaproic acid but not aprotinin. There was a significant reduction in total hospital use of cryoprecipitate, frozen plasma, platelets, and red cells in the aprotinin-treated patients. This reduction was seen during the anhepatic and reperfusion stages of liver transplantation. There was no difference in bl...Continue Reading

References

Mar 1, 1990·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·D Royston
Feb 1, 1991·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·G HimmelreichH Riess
Jan 1, 1990·Annals of Surgery·G HalffT E Starzl
May 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H LewisT E Starzl
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W C Maddrey, D H Van Thiel
Mar 1, 1985·Transfusion·P ButlerT E Starzl
Nov 1, 1985·Seminars in Liver Disease·T E StarzlB W Shaw

❮ Previous
Next ❯

Citations

Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Victor W Xia, Randolph H Steadman
Mar 27, 1998·American Journal of Surgery·Y OzoğulI Sayek
May 17, 2000·Transplantation Proceedings·R P Kufner
May 22, 1998·Transplantation Proceedings·R P Kufner
Mar 27, 2003·Journal of Clinical Anesthesia·James Y Findlay, Ronald P Kufner
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·S M MaksanE Klar
Mar 26, 2003·Pediatric Transplantation·Toni M RentoulAlbert Shun
Aug 11, 2017·Anesthesia and Analgesia·Katherine T ForkinJulie L Huffmyer
Aug 1, 1997·Anesthesiology·M SopherM Csete
Jul 13, 2006·International Anesthesiology Clinics·Theo H N Groenland, Robert J Porte
Jun 3, 2016·Critical Care Nursing Quarterly·Sarah Tischer, James T Miller
Dec 16, 2003·American Journal of Clinical Pathology·Yeu-Chin ChenChin-Yang Li
Nov 22, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·M A BedirhanO Taşçi
May 1, 2021·ANZ Journal of Surgery·Lowell LeowJohn Kit Chung Tam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved