Aprotinin to decrease bleeding and intraoperative blood transfusion requirements during descending thoracic and thoracoabdominal aortic aneurysmectomy using cardiopulmonary bypass

Annals of Vascular Surgery
G GodetP Viars

Abstract

The purpose of this retrospective study was to assess the efficacy of aprotinin, an antifibrinolytic agent, in reducing bleeding and blood transfusion requirements in patients undergoing descending thoracic or thoracoabdominal aortic aneurysmectomy using cardiopulmonary bypass (CPB). Sixty-nine consecutive patients underwent thoracic or thoracoabdominal aneurysmectomy using CPB in a 2-year period. None of the 29 patients operated on in 1990 (group 1) received aprotinin, whereas all 40 patients operated on in 1991 (group 2) were placed on a high-dose regimen of aprotinin. There were no significant differences between the two groups. Administration of aprotinin was associated with a decrease in CPB time (p = 0.02), surgical duration (p = 0.05) and intraoperative blood loss (p = 0.008) as well as a reduction in intraoperative packed red cells (p = 0.01), Cell-Saver units (p = 0.05), fresh-frozen plasma units (p = 0.002), and platelet concentrate (p = 0.01) requirements. These data suggest that aprotinin is effective in reducing bleeding and blood transfusion requirements during descending thoracic or thoracoabdominal aortic aneurysmectomy using CPB.

References

Dec 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·J A Kaplan
Dec 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·F G Estafanous
Dec 1, 1987·The Annals of Thoracic Surgery·W van OeverenC R Wildevuur

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Citations

Jul 6, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Charles Marc Samama
Aug 9, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Linda Shore-LessersonDavid L Reich
Sep 21, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P J BaylyM G Wyatt
Jul 30, 2002·Anesthesia and Analgesia·Charles Marc SamamaPierre Coriat
Jul 9, 2004·Orthopedics·Charles Marc Samama

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