Aptamer-based technology for radionuclide targeted imaging and therapy: a promising weapon against cancer

Expert Review of Medical Devices
Luca FilippiClara Nervi

Abstract

aptamers are short artificial, single-strand oligonucleotide sequences (DNA, RNA or modified RNA), capable of binding to biological molecules with high affinity and specificity. Due to their relatively low cost of production and scarce immunogenicity, many efforts have been made to produce aptamers directed against specific molecular targets, such as receptors or transporters overexpressed by malignancies. the technological approaches for generating aptamers are reviewed. Furthermore, the applications of radiolabeled aptamers for the in vivo imaging of several oncological biomarkers through single photon emission computed tomography (SPECT) or positron emission tomography (PET), are covered. Lastly, targeted therapy based on the utilization of aptamers labeled with radionuclides emitting beta particles is discussed, with particular emphasis to the oncological perspectives. The main limitation of radiolabeled aptamers is represented by their in vivo sensitivity to endogenous nuclease, so that several strategies have been developed to increase the stability of these compounds. Although the applications of aptamers are still in a preliminary and pre-clinical phase, it is reasonable to hypothesize that this technology will play a m...Continue Reading

References

Aug 30, 1990·Nature·A D Ellington, J W Szostak
Feb 5, 2000·Science·T Hermann, D J Patel
Dec 6, 2001·The Journal of Biological Chemistry·Jaekwon LeeDennis J Thiele
Mar 7, 2006·Nature Reviews. Drug Discovery·Eugene W M NgAnthony P Adamis
Mar 20, 2008·Nuclear Medicine Communications·Arman Rahmim, Habib Zaidi
Oct 31, 2008·RNA·Stephen B LongBruce A Sullenger
Jun 12, 2010·Nature Protocols·Kwame SefahWeihong Tan
Sep 25, 2012·Nuclear Medicine and Biology·Melissa A DeriJason S Lewis
Oct 10, 2012·Bioconjugate Chemistry·Sonia Da Rocha GomesJean-Jacques Toulmé
Jan 16, 2013·Chemotherapy Research and Practice·Zahi MitriRuth O'Regan
Apr 9, 2013·Nature Biotechnology·Michiko KimotoIchiro Hirao
Oct 9, 2013·Journal of Drug Targeting·Kambiz VarmiraSeyed Mohammad Abedi
Jan 1, 2014·Nuclear Medicine and Biology·Junling LiChin K Ng
Feb 4, 2014·Current Topics in Medicinal Chemistry·Erin L ColePeter J H Scott
Mar 29, 2014·Bioorganic & Medicinal Chemistry Letters·Cristiane Rodrigues CorreaAntero Silva Ribeiro de Andrade
Feb 24, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Orit JacobsonXiaoyuan Chen
Feb 27, 2016·Current Opinion in Structural Biology·Amy D GelinasNebojsa Janjic
Nov 4, 2016·Nature Reviews. Drug Discovery·Jiehua Zhou, John Rossi
Aug 3, 2017·International Journal of Molecular Sciences·Shuaijian NiGe Zhang
Oct 19, 2017·International Journal of Molecular Sciences·Zhenjian ZhuoBaoting Zhang
Aug 3, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Siyuan ChengXiaoyuan Chen
Oct 17, 2018·Drug Design, Development and Therapy·Bianca GutfilenGianluca Valentini
Dec 28, 2018·Pharmaceuticals·Umair KhalidSarah Shigdar
Jan 27, 2019·PloS One·Hyun Jeong KimWon Jun Kang
Dec 24, 2019·Acta Pharmaceutica Sinica. B·Chong LiYiguang Jin
Mar 12, 2020·Expert Review of Medical Devices·Luca FilippiOreste Bagni

❮ Previous
Next ❯

Citations

Nov 21, 2020·Expert Review of Molecular Diagnostics·Luca FilippiOreste Bagni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biotechnology
S Wölfl, S Diekmann
American Journal of Clinical Pathology
Geoffrey S Baird
Analytical and Bioanalytical Chemistry
Marco Mascini
Nature Structural Biology
H A Heus
© 2021 Meta ULC. All rights reserved