Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle

Current Drug Targets
Jobin JoseBijo Mathew

Abstract

Implementation of novel and biocompatible polymers in drug design is an emerging and rapidly growing area of research. Even though we have a large number of polymer materials for various applications, the biocompatibility of these materials remains as a herculean task for researchers. Aptamers provide a vital and efficient solution to this problem. They are usually small (ranging from 20 to 60 nucleotides, single-stranded DNA or RNA oligonucleotides which are capable of binding to molecules possessing high affinity and other properties like specificity. This review focuses on different aspects of Aptamers in drug discovery, starting from its preparation methods and covering the recent scenario reported in the literature regarding their use in drug discovery. We address the limitations of Aptamers and provide valuable insights into their future potential in the areas regarding drug discovery research. Finally, we explained the major role of Aptamers like medical imaging techniques, application as synthetic antibodies, and the most recent application, which is in combination with nanomedicines.

References

Aug 30, 1990·Nature·A D Ellington, J W Szostak
May 28, 1996·Biochemistry·Y LiD Sen
Aug 10, 2001·Current Opinion in Structural Biology·A C ChengA D Frankel
Jan 8, 2004·Journal of the American Chemical Society·Shaun D Mendonsa, Michael T Bowser
Jun 4, 2004·Nature Biotechnology·Karl Thiel
Mar 7, 2006·Nature Reviews. Drug Discovery·Eugene W M NgAnthony P Adamis
Apr 28, 2006·Expert Opinion on Drug Delivery·Omid C FarokhzadRobert Langer
Jun 17, 2006·Cancer Research·Ted C ChuMatthew Levy
Nov 14, 2006·Angewandte Chemie·Vaishali BagalkotSangyong Jon
Aug 19, 2007·Chembiochem : a European Journal of Chemical Biology·Mehmet Veysel YigitYi Lu
Aug 25, 2007·Chemical Reviews·Michael FamulokGünter Mayer
Jan 5, 2008·Biotechnology Letters·Hijiri HasegawaKazunori Ikebukuro
Apr 4, 2008·Nature·Samir M HanashVitor M Faca
Oct 11, 2008·Nature Biotechnology·Jay Shendure, Hanlee Ji
Mar 21, 2009·Analytical Chemistry·Chun-Yang Zhang, Lawrence W Johnson
Dec 10, 2009·Nature Reviews. Genetics·Michael L Metzker
Jun 12, 2010·Nature Protocols·Kwame SefahWeihong Tan
Jul 2, 2010·Nature Reviews. Drug Discovery·Anthony D KeefeAndrew Ellington
Jul 20, 2010·Interdisciplinary Sciences, Computational Life Sciences·J Torin HuzilJack A Tuszynski
Jan 12, 2011·Analytical Chemistry·Colin D MedleyJoshua E Smith
Apr 19, 2011·Chemical Biology & Drug Design·Chih-Yuan TsengJack A Tuszynski
Sep 10, 2011·Journal of Nucleic Acids·Cindy MeyerAndrea Rentmeister
Oct 22, 2011·Advanced Drug Delivery Reviews·Liu YangWeihong Tan
Feb 24, 2012·PloS One·Harleen Kaur, Lin-Yue Lanry Yung
Apr 11, 2012·International Journal of Molecular Sciences·Mao YeWeihong Tan
Aug 7, 2012·Angewandte Chemie·Jan L VinkenborgMichael Famulok
Sep 26, 2012·Chemical Biology & Drug Design·Mohammad AshrafuzzamanJack A Tuszynski
Nov 13, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Padma SundaramJacek Wower
Dec 25, 2012·Therapeutic Delivery·Duncan Hieu M DamTeri W Odom
Mar 21, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yu Jin LeePann-Ghill Suh
May 2, 2013·Biotechnology Advances·Filip RadomFilip Jeleń
Jun 13, 2013·Chemistry, an Asian Journal·Jian WangWeihong Tan
Jul 19, 2013·Molecular Therapy. Nucleic Acids·Olcay BoyaciogluWilliam H Gmeiner
Jul 31, 2013·Pharmaceuticals·Luiza I HernandezPaloma H Giangrande
Nov 28, 2013·Nucleic Acid Therapeutics·Md AshrafuzzamanJack A Tuszynski
Jan 8, 2014·Proteomics·Bridget LolloLarry Gold
Feb 15, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andrew Z Wang, Omid C Farokhzad
Aug 12, 2014·Trends in Genetics : TIG·Erwin L van DijkClaude Thermes
Aug 19, 2014·ChemMedChem·Sven KruspeUlrich Hahn

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