Aptamers selected by cell-SELEX for application in cancer studies.

Bioanalysis
Yunfei ZhangWeihong Tan

Abstract

Rapid development of anticancer therapies has occurred, but many challenges remain, including difficulties in early detection and the side effects from chemotherapy. To address these problems, aptamers, which are single-stranded DNA or RNA oligonucleotides with high selectivity, affinity and stability, have attracted considerable attention for biomedical applications. These oligonucleotides, which are selected by an in vitro process known as cell systematic evolution of ligands by exponential enrichment (cell-SELEX), have demonstrated the merits required to recognize disease cells. As such, they show great potential for applications in both clinical and laboratory settings. This review focuses on recently developed techniques utilizing aptamers in cancer research, including cancer cell detection, sorting and enrichment, as well as targeted drug delivery for cancer therapy.

References

Aug 30, 1990·Nature·A D Ellington, J W Szostak
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·R B WeissB Leyland-Jones
Jun 1, 1997·Current Opinion in Chemical Biology·S E OsborneA D Ellington
Sep 15, 1998·Bioconjugate Chemistry·M C WillisB Collins
May 2, 2003·Analytical Chemistry·Yaxin JiangChunli Bai
Jun 20, 2003·Progress in Lipid Research·P Sapra, T M Allen
Dec 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dion A DanielsLarry Gold
Oct 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wei GuShuichi Takayama
Feb 24, 2006·Biosensors & Bioelectronics·Ted C ChuAndrew D Ellington
Apr 29, 2006·Analytical Chemistry·Joshua K HerrWeihong Tan
Apr 29, 2006·Analytical Chemistry·Joshua S MarcusStephen R Quake
May 9, 2006·Current Opinion in Chemical Biology·Naveen K Navani, Yingfu Li
Jul 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dihua ShangguanWeihong Tan
Dec 19, 2006·Molecular Cancer Therapeutics·Christopher R Ireson, Lloyd R Kelland
Mar 14, 2007·Analytical Chemistry·Joshua E SmithWeihong Tan
May 29, 2007·Analytical Chemistry·Zhiwen TangWeihong Tan
Aug 25, 2007·Chemical Reviews·Michael FamulokGünter Mayer
Jan 2, 2008·Analytical Chemistry·Yu-Fen HuangWeihong Tan
Jan 16, 2008·Accounts of Chemical Research·Steven M ShamahSharon T Cload
Jan 18, 2008·Analytical Chemistry·Colin D MedleyWeihong Tan
Mar 14, 2008·ChemMedChem·Hui William ChenWeihong Tan
Mar 28, 2008·Journal of Proteome Research·Dihua ShangguanWeihong Tan
May 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hongtao ChenJi-Xin Cheng
Jun 3, 2008·Angewandte Chemie·Marie-Sophie L RaddatzGünter Mayer
Jun 19, 2008·Journal of the American Chemical Society·Maxim V BerezovskiSergey N Krylov
Jan 1, 2009·Analytical Chemistry·Joseph A PhillipsWeihong Tan
Mar 4, 2009·Chembiochem : a European Journal of Chemical Biology·Yu-Fen HuangWeihong Tan
Sep 23, 2009·Bioconjugate Chemistry·Laurent Ducry, Bernhard Stump
Dec 22, 2009·Chemical Communications : Chem Comm·Huaizhi KangWeihong Tan
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yanrong WuWeihong Tan

❮ Previous
Next ❯

Citations

Mar 22, 2013·BioResearch Open Access·Shoji Ohuchi
Apr 16, 2014·The Analyst·Wenhu ZhouJuewen Liu
Jan 29, 2016·Experimental Cell Research·Aline G SouzaVivian A Goulart
Apr 9, 2013·Pharmacological Reports : PR·Jolanta B ZawilskaAgnieszka B Olejniczak
Feb 13, 2016·The Analyst·Muslum Ilgu, Marit Nilsen-Hamilton
Jan 4, 2012·Angewandte Chemie·Marco MasciniSara Tombelli
Mar 17, 2016·Critical Reviews in Analytical Chemistry·Sze Y TanMichael K Danquah
Oct 22, 2016·Biomaterials·Si-Yong QinXian-Zheng Zhang
Dec 16, 2016·International Journal of Molecular Sciences·Man ChenGe Zhang
Oct 4, 2012·Nucleic Acid Therapeutics·Partha RayRebekah R White
Nov 16, 2017·Cancers·Tatiana N ZamayAnna S Kichkailo
May 14, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ying LiangYongxiang Zhao
Sep 1, 2015·Biomedicines·Joy Sebastian Prakash, Karunanithi Rajamanickam
Oct 17, 2017·Analytical and Bioanalytical Chemistry·Bruno P CrulhasValber A Pedrosa
Dec 7, 2018·International Journal of Molecular Sciences·Min Woo KimAeju Lee
Jul 20, 2017·Applied Biochemistry and Biotechnology·Maryam Sadat NabaviniaKhalil Abnous
Oct 3, 2018·Pharmaceuticals·Philisiwe Fortunate MolefeAbidemi Paul Kappo
Mar 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yujie SunGuojun Zhang
Jul 7, 2020·Engineering in Life Sciences·Sandra WittJohanna-Gabriela Walter
Jan 13, 2018·Analytical Chemistry·Sarah J Reinholt, Harold G Craighead

❮ Previous
Next ❯

Methods Mentioned

BETA
antisense oligonucleotides

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.