Aptasensor Based on Hierarchical Core-Shell Nanocomposites of Zirconium Hexacyanoferrate Nanoparticles and Mesoporous mFe3 O4 @mC: Electrochemical Quantitation of Epithelial Tumor Marker Mucin-1

ACS Omega
Minghua WangZhihong Zhang

Abstract

A novel nanostructured hierarchical core-shell nanocomposite of zirconium hexacyanoferrate (ZrHCF) and a mesoporous nanomaterial composed of Fe3O4 and carbon nanospheres (denoted as ZrHCF@mFe3O4@mC) was prepared and used as a novel platform for an aptasensor to detect the epithelial tumor marker mucin-1 (MUC1) sensitively and selectively. The prepared ZrHCF@mFe3O4@mC nanocomposite exhibited good chemical functionality, water stability, and high specific surface area. Therefore, large amounts of aptamer molecules resulted in high sensitivity of the developed electrochemical aptasensor toward traces of MUC1. The constructed sensor also showed a good linear relationship with the logarithm of MUC1 concentration in the broad range of 0.01 ng·mL-1 to 1.0 μg·mL-1, with a low detection limit of 0.90 pg·mL-1. The fabricated ZrHCF@mFe3O4@mC-based aptasensor exhibited not only high selectivity because of the formation of aptamer-MUC1 complex but also good stability, acceptable reproducibility, and applicability. The proposed novel strategy based on a newly prepared hierarchical core-shell nanocomposite demonstrated outstanding biosensing performance and presents potential applications in biomedical fields.

References

Sep 8, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Jon LaddShaoyi Jiang
Apr 28, 2005·Biosensors & Bioelectronics·S TombelliM Mascini
Feb 16, 2006·Journal of the American Chemical Society·Jacob A HansenGreg Collins
Oct 13, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·C S M FerreiraS Missailidis
Mar 12, 2009·Journal of the American Chemical Society·Chenjie XuShouheng Sun
Sep 16, 2009·Accounts of Chemical Research·Xiaohong Fang, Weihong Tan
Feb 22, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Falk BernsmannDavid Ruch
May 11, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Qiyu YuXun Wang
May 22, 2013·Current Drug Metabolism·Bruna ScaggianteGabriele Grassi
Oct 31, 2013·Chemical Society Reviews·Yiting TangHua-Zhong Yu
Dec 3, 2014·Acta Biomaterialia·Tina MickschBernd Schwenzer
Nov 17, 2015·ACS Applied Materials & Interfaces·Hui WangWenwan Zhong
Sep 17, 2016·Cancer Biomarkers : Section a of Disease Markers·Juan WangGuixiang Tai

❮ Previous
Next ❯

Methods Mentioned

BETA
biosensors
enzyme-linked
surface plasmon resonance
biosensing
DNA array
biosensor
X-ray
electron diffraction
quartz crystal microbalance
aptasensor

Software Mentioned

ZView

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.