PMID: 6159695May 1, 1980Paper

APUD cells and neuroepithelial bodies in hamster lung: methods, quantitation, and response to injury

Thorax
J R Palisano, J Kleinerman

Abstract

A comparative study of the Falck-Hillarp Technique, a modification of Eaton-Fedde procedure and silver staining of aldehyde-fixed tissue was carried out to determine the most efficient procedure to demonstrate neuroendocrine cells of the hamster and rat lung. The modified Eaton-Fedde procedure is the most efficient method of observing these cells, and is also the easiest to perform. With this method, the normal hamster lung contains a total of 2.00 x 10(-1) to 3.00 x 10(-1) neuroendocrine cells/mm in the small and large bronchioles. In the larger airways approximately 3.51 x 10(-1) neuroepithelial bodies (NEB)/mm are observed. Immediately after 24-hour exposure to NO2 the number of APUD cells dropped to approximately 25% of the control levels. These cells were decreased to 50% of the control levels throughout the 28 days of exposure. The number of NEB decreased transiently after 24 hours of NO2 but returned to normal numbers by day 14. We recommend the application of fluorescence techniques coupled with standardised sections and quantitative methods of study for analysis of APUD cells and NEB.

References

Jul 1, 1976·Stain Technology·J S Fernandez Pascual
Jan 12, 1977·Cell and Tissue Research·J A Eaton, M R Fedde
Jul 1, 1977·The Journal of Pathology·W Taylor
Jan 1, 1976·Archives of Environmental Health·J Kleinerman, D Rynbrandt
Mar 1, 1973·The Annals of Otology, Rhinology, and Laryngology·K Bak-Pedersen, M Tos
Nov 1, 1973·Thorax·H MoosaviD Heath
Jun 1, 1969·Life Sciences·J M Lauweryns, J C Peuskens
Jan 1, 1971·Histochemie. Histochemistry. Histochimie·A G Pearse, J M Polak
Apr 17, 1969·Histochemie. Histochemistry. Histochimie·R HåkansonC Owman
Jan 1, 1954·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·F FEYRTER
Aug 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H CORRODIG JONSSON
Jan 1, 1965·Journal of Neuropathology and Experimental Neurology·A C SEVIER, B L MUNGER
Feb 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B HAMBERGERC SACHS

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·H M SchullerJ B McMahon
Apr 1, 1984·Environmental Health Perspectives·R P DiAugustine, K S Sonstegard
Jun 1, 1990·Anatomia, histologia, embryologia·A Gomez-PascualH Galera
May 1, 1993·The Anatomical Record·D Adriaensen, D W Scheuermann
Nov 1, 1982·Experimental Lung Research·R F HoytS P Sorokin
Jan 1, 1985·Experimental Lung Research·R DayS Lemaire
Jan 1, 1987·Experimental Lung Research·T G ChristensenG L Snider
Feb 1, 1997·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T ItoM Kanisawa
May 1, 1985·The American Journal of Anatomy·V H CarabbaR F Hoyt
Jan 1, 1991·Pediatric Pathology·Y Nakatani
Oct 31, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Somshuvra MukhopadhyayPravin B Sehgal
Mar 6, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pravin B SehgalMehul Shah

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