Apurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma.

Antioxidants & Redox Signaling
Sun Yang, F L Meyskens

Abstract

Management of melanoma is a growing and challenging public health issue requiring novel and multidisciplinary approaches to achieve more efficient prevention and therapeutic benefits. The aim of this article is to show the critical role of APE/Ref-1 on melanomagenesis and progression. APE/Ref-1 serves as a redox-sensitive node of convergence of various signals as well as a DNA-repair enzyme, and its activation protects melanocytes and melanoma cells from chronic oxidative stress and promotes cell survival via mediation of downstream pathways. APE/Ref-1 is a strong candidate as a potential drug-treatable target for the prevention and treatment of human melanoma. Lead compounds exhibiting inhibitory effects on APE/Ref-1 are also reviewed. We anticipate potential clinical benefit in the future through inhibition of APE/Ref-1 and/or Ref-1-mediated signaling.

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Citations

Aug 22, 2008·Antioxidants & Redox Signaling·Byeong Hwa Jeon, Kaikobad Irani
Jun 6, 2009·Antioxidants & Redox Signaling·Georg T Wondrak
Dec 19, 2015·Oxidative Medicine and Cellular Longevity·Stéphanie Anaís CastaldoPatrícia Alexandra Madureira
Feb 6, 2014·Journal of Inorganic Biochemistry·Eric L Carter, Stephen W Ragsdale
Oct 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hye-Mi LeeEun-Kyeong Jo

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Methods Mentioned

BETA
chemical treatments
biopsies
flow cytometry
transfection
chemical modification
nuclear translocation

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