Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls and genotype-phenotype correlations

Archives of Dermatology
David R BerkSusan J Bayliss

Abstract

To determine the prevalence of aquagenic wrinkling of the palms (AWP) in patients with cystic fibrosis (CF) compared with control patients, and evaluate for genotype-phenotype correlations. Since its first description over 30 years ago, AWP has frequently been anecdotally associated with CF, but this association has not been confirmed in a rigorous prospective case-control study. Blinded comparison. The CF and dermatology clinics at St Louis Children's Hospital. Forty-four individuals with CF from a CF clinic and 26 controls from a dermatology clinic. Intervention Participants were tested for AWP using 3 minutes of water immersion with room-temperature tap water. Main Outcome Measure The degree of AWP was scored from 0 (no wrinkling) to 4 (severe wrinkling) by 3 blinded physicians. For genotype-phenotype correlations, patients with CF were divided into those homozygous for the DeltaF508 mutation and those with other genotypes. The mean AWP score of the CF group was significantly higher than the mean score of the control group (1.5 vs 0.6; P < .001). Patients with CF who were homozygous for the DeltaF508 mutation (n = 27) had significantly higher scores than patients with CF who were not homozygous for the DeltaF508 mutation (n ...Continue Reading

Citations

Oct 21, 2011·The Journal of Dermatology·Rachel Vale, David N Adam
Jun 8, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Sonja Ständer
Feb 17, 2018·The British Journal of Dermatology·H KaiserA Bygum
Mar 23, 2010·The British Journal of Dermatology·N Garçon-MichelL Misery
Sep 30, 2010·The British Journal of Dermatology·R Phillips
Jul 31, 2013·Journal of Strength and Conditioning Research·Douglas P LewisTamara D Hew-Butler
Nov 3, 2011·Pediatric Dermatology·Ligaya ParkJoan Tamburro
Apr 20, 2012·The British Journal of Dermatology·F RongiolettiL Marchesi
Feb 6, 2013·Journal of Cutaneous Pathology·Katherine BaquerizoGeorge W Elgart
Nov 25, 2020·Pediatric Clinics of North America·Bernard A Cohen, Nelson L Turcios
May 22, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Grace R PaulKaren S McCoy
Jul 18, 2021·Clinics in Dermatology·Laura AtzoriFranco Rongioletti
Apr 30, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·A AlexopoulosA Michos
May 15, 2012·Annales de dermatologie et de vénéréologie·C TrototA Barbaud

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.