Abstract
Transmural-pressure (ΔP)-driven plasma advection carries macromolecules into the vessel wall, the earliest prelesion atherosclerotic event. The wall's hydraulic conductivity, LP, the water flux-to-ΔP ratio, is high at low pressures, rapidly decreases, and remains flat to high pressures (Baldwin AL, Wilson LM. Am J Physiol Heart Circ Physiol 264: H26-H32, 1993; Nguyen T, Toussaint, Xue JD, Raval Y, Cancel CB, Russell LM, Shou S, Sedes Y, Sun O, Yakobov Y, Tarbell JM, Jan KM, Rumschitzki DS. Am J Physiol Heart Circ Physiol 308: H1051-H1064, 2015; Tedgui A, Lever MJ. Am J Physiol Heart Circ Physiol. 247: H784-H791, 1984. Shou Y, Jan KM, Rumschitzki DS. Am J Physiol Heart Circ Physiol 291: H2758-H2771, 2006) due to pressure-induced subendothelial intima (SI) compression that causes endothelial cells to partially block internal elastic laminar fenestrae. Nguyen et al. showed that rat and bovine aortic endothelial cells express the membrane protein aquaporin-1 (AQP1) and transmural water transport is both transcellular and paracellular. They found that LP lowering by AQP1 blocking was perplexingly ΔP dependent. We hypothesize that AQP1 blocking lowers average SI pressure; therefore, a lower ΔP achieves the critical force/area on the ...Continue Reading
References
Sep 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S J LinS Chien
Aug 1, 1991·Journal of Biomechanical Engineering·F YuanS Weinbaum
Mar 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S J LinS Chien
Oct 1, 1988·Atherosclerosis·S J LinS Chien
Nov 21, 1988·Journal of Theoretical Biology·G B WenS Chien
Oct 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J R Levick
Mar 1, 1988·Microvascular Research·J M TarbellC G Caro
Oct 1, 1986·Circulation Research·F E Curry
Jun 1, 1985·The American Journal of Physiology·S WeinbaumS Chien
Nov 1, 1984·The American Journal of Physiology·A Tedgui, M J Lever
Jan 1, 1983·Canadian Journal of Physiology and Pharmacology·R F Potter, M R Roach
Jul 1, 1980·Microvascular Research·F E Curry, C C Michel
Nov 1, 1994·Journal of Biomechanical Engineering·Y HuangS Weinbaum
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S NielsenP Agre
Jan 1, 1993·The American Journal of Physiology·A L Baldwin, L M Wilson
Apr 1, 1997·The American Journal of Physiology·Y HuangS Weinbaum
Jul 1, 1997·The American Journal of Physiology·Z J Huang, J M Tarbell
Jul 21, 1999·Journal of Biomechanical Engineering·Y HuangS Weinbaum
Oct 18, 2000·Nature·K MurataY Fujiyoshi
Jul 19, 2001·Annals of Biomedical Engineering·S Tada, J M Tarbell
Jun 8, 2002·Journal of Structural Biology·J M SquireC Michel
Aug 13, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·Julia VoigtlaenderBernhard F Becker
Mar 26, 2003·Annual Review of Biomedical Engineering·John M Tarbell
Sep 27, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Xiaobing ZhangSheldon Weinbaum
May 30, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Yixin ShouDavid S Rumschitzki
Aug 15, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Xiaobing ZhangSheldon Weinbaum
May 5, 1896·The Journal of Physiology·E H Starling
Nov 28, 2006·FEBS Letters·Baoxue YangA S Verkman
Mar 22, 2007·Annual Review of Biomedical Engineering·Sheldon WeinbaumEdward R Damiano
Jul 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mahsa DabaghJohn M Tarbell
Jun 8, 2011·Journal of Theoretical Biology·Xiao LiuXiaoyan Deng
Dec 27, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Zhongqing ZengDavid S Rumschitzki
Feb 11, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Tieuvi NguyenDavid S Rumschitzki