PMID: 7541952Jun 1, 1995Paper

Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney

The American Journal of Physiology
S NielsenArvid B Maunsbach

Abstract

The localization of aquaporin-1 water channels (AQP-1) in nephron and vascular structures in rat kidney were characterized, because vascular bundles are known to play a key role in urinary concentration. Immunohistochemistry and immunoelectron microscopy were applied on thin cryosections or ultrathin Lowicryl sections, using an optimized freeze-substitution method. Within the vascular bundles, AQP-1 is localized in descending thin limbs (DTL) of short nephrons in apical and basolateral membranes. The expression in DTL of short nephrons is considerably lower compared with the expression in long nephrons, consistent with the known lower osmotic water permeability of this segment. Furthermore, DTL of short nephrons expressing AQP-1 continue abruptly into a thin limb segment without AQP-1. This suggests the existence of a novel thin limb epithelium in the outer medulla. Extensive expression of AQP-1 is observed in apical and basolateral membranes of DTL of long nephrons, which are localized in the periphery of the vascular bundles. The expression decreases along the axis of long nephron DTLs in correlation with the known water permeability characteristics of thin limb segments. DTLs of both short and long nephrons continue abruptly...Continue Reading

Citations

Aug 15, 2000·Journal of Cellular Physiology·K Lange
Mar 16, 2001·American Journal of Physiology. Renal Physiology·L N NejsumS Nielsen
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·P T HurleyR M Case
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Aug 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tadeh IssaianThomas L Pannabecker
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