PMID: 15224873Jul 1, 2004Paper

Aquaporin-2 in the human endolymphatic sac

Acta Oto-laryngologica
Vincent CouloignerEvelyne Ferrary

Abstract

To detect and localize aquaporin-2 (AQP-2), a water channel regulated by the antidiuretic hormone, in human endolymphatic sac. Human endolymphatic sacs were sampled during removal of vestibular schwannomas via a translabyrinthine approach. Samples were immediately fixed in 10% formalin (24 h) and embedded in paraffin; in situ hybridization and immunohistochemistry were performed with an AQP-2-specific probe and a polyclonal antibody. Both AQP-2 mRNA and protein were detected in the epithelium of the endolymphatic sac. AQP-2 immunostaining was mainly cytoplasmic, suggesting that most AQP-2 was located in intracellular pools. In the endolymphatic sac, AQP-2 probably participates in the homeostasis of endolymph; the possibility of reducing the volume of endolymph by inhibiting its expression and membranous insertion using an antidiuretic hormone inhibitor represents a new therapeutic approach for the treatment of Ménière's disease.

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Citations

Jul 9, 2008·Acta Oto-laryngologica·Daizo TaguchiHiroya Kitano
Mar 25, 2008·The Annals of Otology, Rhinology, and Laryngology·Vincent CouloignerEvelyne Ferrary
Feb 14, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Marc-Henri AsmarIssam Saliba
Sep 16, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Gail IshiyamaAkira Ishiyama
Oct 9, 2019·The Laryngoscope·Sung Hwa DongSeung Geun Yeo
Sep 27, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Vania CunaGaetano La Manna
Nov 3, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Nozomu MoriHiroshi Hoshikawa
Feb 24, 2007·Cell and Tissue Research·Ivan A LopezAkira Ishiyama
Jul 9, 2008·Auris, Nasus, Larynx·Akinobu KakigiRie Nishioka

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