Apr 1, 2016

Aquaporin-4 and Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Canhong YangTianming Lü


Alzheimer's disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water transporter. However, the distribution and expression of AQP4 are altered in both AD clinical populations and animal models. Recent studies have revealed that AQP4 is important to the clearance of Aβ in brain via lymphatic clearance, transcytotic delivery, and glial degradation, as well as to the synaptic function. Thus, AQP4 likely plays an important role in the pathogenesis of AD. Further studies would provide new targets for prevention, ultimately leading to improved treatment options for AD.

  • References67
  • Citations2

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Pathogenic Aspects
APP protein, human
Transcytotic Pathways
Synaptic Transmission

Related Feeds


Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Alzheimer's Disease: APP

Amyloid precursor protein proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques. Here is the latest research.

Astrocytes & Amyloid

The relationship between astrocytes and amyloid has been suggested in some neurological diseases such as Alzheimer’s disease. Neuronal damage stimulates the activation of reactive astrocytes, which may the source of amyloid that forms in Alzheimer’s. Here is the latest research on astrocytes and amyloid.

Alzheimer's Disease: Animal models

Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Abeta

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.

Alzheimer's Disease: RNA Regulation

RNA regulation involves several mechanisms that are used by cells to decreases or increase the production of RNA. Issues with RNA regulation are associated with Alzheimer's Disease (AD). Here are the latest discoveries pertaining to RNA regulation and this disease.

Related Papers

Journal of Alzheimer's Disease : JAD
Kai YangJohn F MacDonald
Cold Spring Harbor Perspectives in Biology
Morgan ShengThomas C Südhof
© 2020 Meta ULC. All rights reserved