Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression

Glia
Brana RosicErlend A Nagelhus

Abstract

Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurological disease states. CSD is characterized by massive ion dyshomeostasis, cell swelling, and multiphasic blood flow changes. Recently, it was shown that CSD is associated with a closure of the paravascular space (PVS), a proposed exit route for brain interstitial fluid and solutes, including excitatory and inflammatory substances that increase in the wake of CSD. The PVS closure was hypothesized to rely on swelling of astrocytic endfeet due to their high expression of aquaporin-4 (AQP4) water channels. We investigated whether CSD is associated with swelling of endfeet around penetrating arterioles in the cortex of living mice. Endfoot cross-sectional area was assessed by two-photon microscopy of mice expressing enhanced green fluorescent protein in astrocytes and related to the degree of arteriolar constriction. In anesthetized mice CSD triggered pronounced endfoot swelling that was short-lasting and coincided with the initial arteriolar constriction. Mice lacking AQP4 displayed volume changes o...Continue Reading

References

Jan 12, 1993·Neuroscience Letters·V I Koroleva, J Bures
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Coert J ZuurbierCan Ince
Jun 22, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa R ReganJeffrey D Rothstein
Jun 18, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Richard H SmithRobert M Kotin
Jul 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wannan TangRolf Sprengel
Sep 22, 2010·Cephalalgia : an International Journal of Headache·Didem AkcaliHayrunnisa Bolay
Nov 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martin LauritzenAnthony John Strong
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alexander S ThraneErlend A Nagelhus
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Valentina BenfenatiMahmood Amiry-Moghaddam
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alexander Stanley ThraneMaiken Nedergaard
Jul 3, 2013·Science·Maiken Nedergaard
Sep 18, 2013·Nature Reviews. Neurology·Andrew C Charles, Serapio M Baca
Nov 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey J IliffMaiken Nedergaard
Feb 14, 2015·Fluids and Barriers of the CNS·Stephen B Hladky, Margery A Barrand
Mar 13, 2015·Frontiers in Cellular Neuroscience·Karolina SzokolErlend A Nagelhus
Apr 4, 2015·Cerebral Cortex·Rune EngerErlend A Nagelhus
May 23, 2015·Neuron·Jens P Dreier, Clemens Reiffurth
Jun 17, 2015·The Journal of Experimental Medicine·Aleksanteri AspelundKari Alitalo
Jul 3, 2015·Physiological Reviews·Cenk Ayata, Martin Lauritzen
Sep 5, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annette B SteffensenNanna MacAulay
Oct 2, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew O JoDavid Križaj
Mar 20, 2016·Cellular and Molecular Neurobiology·Erik N T P BakkerRoxana O Carare
Jun 23, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jed A HartingsJens P Dreier
Dec 9, 2016·Scientific Reports·Mahdi AsgariVartan Kurtcuoglu
Feb 15, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron J SchainRami Burstein
Mar 16, 2017·The Journal of Physiology·Trine L Toft-BertelsenNanna MacAulay
Aug 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Karl Erik HolterKlas H Pettersen
Nov 5, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alex J Smith, Alan S Verkman
Feb 13, 2018·Acta Neuropathologica·N Joan AbbottRobert G Thorne
Oct 21, 2018·Fluids and Barriers of the CNS·Stephen B Hladky, Margery A Barrand

❮ Previous
Next ❯

Methods Mentioned

BETA
Transgenic
transfection
PCR

Software Mentioned

Fiji ImageJ
Cell Wand Tool
MATLAB
ImageJ

Related Concepts

Related Feeds

Bartonellosis

Bartonellosis is an infection caused by bacteria in the genus Bartonella and can present as a variety of diseases depending on the organism involved. While asymptomatic infection has been reported, immunocompromised individuals are more susceptible to severe infection. Find the latest research on bartonellosis here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Cat-scratch disease

Cat-scratch disease, a relatively common infectious disease, is caused by Bartonella henselae and characterized by a fever and regional lymphadenitis. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Aaron J SchainRami Burstein
Cephalalgia : an International Journal of Headache
S Bowyer
© 2022 Meta ULC. All rights reserved