Aquaporin 4 is involved in chronic pain but not acute pain.

Behavioural Brain Research
Guanyi LuJin Li

Abstract

Accumulating evidence has revealed that spinal glia plays an important role in the processing of pain, particularly chronic pain. Aquaporin 4 (AQP4), the predominant water channel exists in astrocytes, has been proved to modulate astrocytic function and thus participate in many diseases of the central nervous system. However, there is still controversy over whether AQP4 is involved in pain modulation. In the present study, we investigated the effects of AQP4 on pain by examining chronic inflammatory pain, neuropathic pain, and thermal, chemical, and mechanical stimuli-induced acute pain in AQP4 knockout mice. In Complete Freund's adjuvant-induced chronic inflammatory pain and spared nerve injury-induced neuropathic pain models, AQP4-/- mice attenuated pain-related behavioral responses compared with AQP4+/+ mice, demonstrating that AQP4 deficiency relieved chronic inflammatory pain and neuropathic pain. In the tail-flick and hot-plate tests, two acute pain models of thermal stimuli, no differences in pain-related behaviors were detected between AQP4+/+ and AQP4-/- mice. In the formalin and capsaicin tests, two models of chemical stimuli-induced acute pain, no differences in the durations of licking the injected hindpaw were foun...Continue Reading

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Oct 12, 2021·Journal of Biomolecular Structure & Dynamics·Emanuela de Lima RebouçasMaria Izabel Florindo Guedes

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