Aquatic multi-species acute toxicity of (chlorinated) anilines: experimental versus predicted data

Chemosphere
Nathalie DomRonny Blust

Abstract

Aquatic toxicity information is essential in environmental risk assessment to determine the potential hazards and risks of new and existing chemicals. Prediction and modelling techniques, such as quantitative structure activity relationships (QSAR) and species sensitivity distributions (SSDs), are applied to fill data gaps and to predict, assess and extrapolate the toxicity of chemicals. In this study, both techniques (i.e. the ECOSAR programme as QSAR tool and SSDs) were assessed for a set of polar narcotic structural analogues that differ in their degree of chloro-substitution (aniline, 4-chloroaniline, 3,5-dichloroaniline and 2,3,4-chloroaniline). The acute toxicity of these compounds was tested in one prokaryote species (Escherichia coli) and three eukaryote aquatic species (Pseudokirchneriella subcapitata, Daphnia magna and Danio rerio). Consequently, the experimental acute toxicity data were compared to the QSAR predictions made by the ECOSAR programme and compared to the species sensitivity modelling results. Large interspecies differences in sensitivity were observed (D. magna>P. subcapitata>D. rerio>E. coli). 4-Chloroaniline acted as an outlier in P. subcapitata toxicity. Whereas in D. magna, toxicity decreased rather ...Continue Reading

References

May 1, 1985·The Science of the Total Environment·Y YoshiokaT Sato
Feb 26, 2004·Environmental Toxicology and Chemistry·Cédric DuboudinHélène Magaud
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Jan 13, 2006·Ecotoxicology and Environmental Safety·Magnus BreitholtzBengt-Erik Bengtsson
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Feb 12, 2008·Chemosphere·Peter ReuschenbachThomas Knacker
Jul 1, 2002·Environmental Toxicology and Pharmacology·Eñaut Urrestarazu RamosJoop L M Hermens

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Citations

Aug 16, 2012·Journal of Industrial Microbiology & Biotechnology·Alisa S VangnaiJunichi Kato
Sep 13, 2011·Bulletin of Environmental Contamination and Toxicology·Enrico Mombelli, Alexandre R R Pery
Dec 17, 2014·Ecotoxicology and Environmental Safety·Ke LiuYunchao Dai
May 7, 2016·Ecotoxicology and Environmental Safety·Yunchao DaiYingfei Cao
Jun 22, 2018·Journal of Applied Microbiology·M GoswamiJ Jass

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