PMID: 15376529Sep 21, 2004Paper

Aquatic persistence of eight pharmaceuticals in a microcosm study

Environmental Toxicology and Chemistry
Monica W LamScott A Mabury

Abstract

The persistence of eight pharmaceuticals from multiple classes was studied in aquatic outdoor field microcosms. A method was developed for the determination of a mixture of acetaminophen, atorvastatin, caffeine, carbamazepine, levofloxacin, sertraline, sulfamethoxazole, and trimethoprim at microg/L levels from surface water of the microcosms using solid phase extraction and high-performance liquid chromatography-ultraviolet (HPLC-UV) and liquid chromatography tandem mass spectrometry (LC-MS-MS). Half-lives in the field ranged from 1.5 to 82 d. Laboratory persistence tests were performed to determine the relative importance of possible loss processes in the microcosms over the course of the study. Results from dark control experiments suggest hydrolysis was not important in the loss of the compounds. No significant differences were observed between measured half-lives of the pharmaceuticals in sunlight-exposed pond water and autoclaved pond water, which suggests photodegradation was important in limiting their persistence, and biodegradation was not an important loss process in surface water over the duration of the study. Observed photoproducts of several of the pharmaceuticals remained photoreactive, which led to further degra...Continue Reading

Citations

Apr 20, 2007·Analytical and Bioanalytical Chemistry·Anne Togola, Hélène Budzinski
Sep 24, 2005·Archives of Environmental Contamination and Toxicology·M OetkenJ Oehlmann
Oct 25, 2007·Archives of Environmental Contamination and Toxicology·M T MooreB Guerra
Nov 1, 2007·Archives of Environmental Contamination and Toxicology·S M RichardsM L Hanson
Aug 18, 2012·Applied Microbiology and Biotechnology·Simone Larcher, Viviane Yargeau
May 1, 2012·Environmental Science and Pollution Research International·Victoria OsorioDamià Barceló
Jan 17, 2012·Environmental Science and Pollution Research International·Juhani Peuravuori
Mar 26, 2004·Regulatory Toxicology and Pharmacology : RTP·Hans SandersonKeith R Solomon
Feb 13, 2013·Environmental Science & Technology·Larry B BarberSteven D Zaugg
Aug 21, 2013·Environmental Science & Technology·Jeffrey H WriterE Michael Thurman
Sep 26, 2012·Journal of Agricultural and Food Chemistry·Rumi TanoueKei Nomiyama
Dec 10, 2013·Water Research·Juying LiJay Gan
Mar 26, 2013·The Science of the Total Environment·Hongxia LiEdward Topp
Jan 5, 2013·The Science of the Total Environment·Sheyla Ortiz de GarcíaRubén Irusta Mata
Jan 3, 2012·The Science of the Total Environment·Marianne StuartAlwyn Hart
Nov 8, 2011·Chemosphere·Laura E JacobsYu-Ping Chin
Aug 23, 2011·The Science of the Total Environment·Allison M Veach, Melody J Bernot
Apr 20, 2010·Environment International·Thomas L ter LaakAnnemarie P van Wezel
Nov 4, 2009·Regulatory Toxicology and Pharmacology : RTP·Virginia L CunninghamRudolf Bechter
May 1, 2009·The Science of the Total Environment·Dror AvisarDaniel Ronen
Jan 29, 2008·The Science of the Total Environment·Fatima TamtamMarc Chevreuil
Sep 14, 2010·Environmental Toxicology and Chemistry·Hannah R FosterEarl E Werner
Mar 24, 2016·Environmental Science and Pollution Research International·Hiroshi YamamotoYudai Nakamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.