Aqueous-based microencapsulation enhances virus-specific humoral immune responses in mice after parenteral inoculation

Vaccine
C A MoserP A Offit

Abstract

Vaccines are commonly administered by the parenteral route. Therefore, adjuvant strategies which include parenteral immunization may improve the efficacy of a number of current vaccines. The capacity of aqueous-based microencapsulation to enhance virus-specific IgG responses in mice inoculated intramuscularly with small quantities of antigen was evaluated. Mice were inoculated with either 10(4), 10(3), or 10(2) p.f.u. of microencapsulated rotavirus (bovine strain WC3), placebo microcapsules plus free virus, or virus alone. Mice were subsequently bled 1, 2, 4, 6, and 9 months after inoculation. Microencapsulation of rotavirus enhanced virus-specific humoral immune responses. In addition, virus-containing microcapsules composed of spermine-chondroitin sulfate induced levels of virus-specific antibodies greater than those found after inoculation with virus-containing microcapsules composed of spermine-alginate. Mechanisms by which microencapsulation may enhance virus-specific humoral immunity are discussed.

References

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Citations

Mar 22, 2000·Journal of Immunological Methods·J O BrubakerP A Offit
Jun 6, 2000·Advanced Drug Delivery Reviews·T L Bowersock, S Martin
Jan 1, 1998·Drug Delivery·R T Patil, T J Speaker
Nov 18, 1998·Journal of Microencapsulation·R T Patil, T J Speaker
Jul 16, 2011·PloS One·Izabela RozenbergFelix C Tanner

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