Aqueous Extract of Argania spinosa L. Fruits Ameliorates Diabetes in Streptozotocin-Induced Diabetic Rats

Cardiovascular & Hematological Agents in Medicinal Chemistry
Morad HebiMohamed Eddouks

Abstract

The argan tree (Argania spinosa L.) is an endemic species from south-western Morocco. Argan-based preparations have been widely used in Moroccan traditional medicine for their biological properties including diabetes especially argan oil. However, the antihypergycemic effect of the pericarp of A. spinosa fruit has never been evaluated. The purpose of this study was to investigate the effect of a single dose and daily oral administration for seven days of aqueous extract of pericarp of Argania spinosa fruit (A.E.P.F.A.S) in normal and streptozotocin (STZ) diabetic rats. The effect of A.E.P.F.A.S. (10 mg/kg) on blood glucose levels, plasma Total Cholesterol (TC) and triglyceride concentrations were measured in both normal and diabetic rats. The antioxidant capacity of the A.E.P.F.A.S was also demonstrated using test of DPPH (1-1-diphenyl 2-picryl hydrazyl). The histopathological changes in liver and pancreas have been evaluated in both normal and STZ diabetic rats. A preliminary phytochemical screening for various bioactive constituents and the antioxidant capacity were realized. Single oral administration of A.E.P.F.A.S reduced blood glucose levels p 6 h after administration in STZ diabetic rats. Furthermore, blood glucose level...Continue Reading

Citations

Jun 13, 2019·Cardiovascular & Hematological Agents in Medicinal Chemistry·Morad Hebi, Mohamed Eddouks
Mar 5, 2019·Cardiovascular & Hematological Agents in Medicinal Chemistry·Morad Hebi, Mohamed Eddouks
Sep 30, 2020·Current Pharmaceutical Design·Kondeti R ShanmugamKesireddy S Reddy

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