Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Diptiman ChoudhuryGopal Chakrabarti

Abstract

Ginger has a long history of use as traditional medicine for varied human disease. Our present study has shown that the aqueous extract of ginger (GAE) interacts directly with cellular microtubules and disrupts its structure and induces apoptosis of cancer cells as well. The IC(50) values of GAE, as determined from cell viability experiment on human non-small lung epithelium cancer (A549) cells and human cervical epithelial carcinoma (HeLa), were 239.4+7.4 and 253.4+8.9 μg/ml, respectively. It has been found that the apoptosis of A549 cells by GAE is mediated by up regulation of tumor suppressor gene p53 and alteration of the normal Bax/Bcl-2 ratio followed by down regulation of cellular pro-caspase3. The morphological change of cells upon GAE treatment has also been demonstrated. Both the structural and functional properties of tubulin and microtubule were lost, as confirmed by both ex vivo and invitro experiments. The major component of GAE is poly-phenols (around 2.5%), which consist of ∼ 80% flavones and flavonols. Poly-phenolic compounds are well known to have anti-mitotic properties, and may be further screened for the development of a potential anti-cancer agent.

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Citations

Jun 25, 2013·Expert Opinion on Investigational Drugs·Su-Juan WangLu-Ping Qin
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Tullayakorn PlengsuriyakarnKesara Na-Bangchang
Nov 1, 2013·Journal of Agricultural and Food Chemistry·Chun-Ting LiuLee-Yan Sheen
Jun 27, 2020·Nutrition and Cancer·Amir Mohammad SaeedifarAli Ganji
Apr 14, 2015·Jundishapur Journal of Natural Pharmaceutical Products·Laleh Khodaie, Omid Sadeghpoor
Oct 8, 2013·Toxicology and Industrial Health·Manal Abdul-Hamid, Marwa Salah
Oct 20, 2020·Journal of Pharmacopuncture·Nour Elhouda Daoudi, Mohamed Bnouham
Dec 15, 2020·Journal of Drug Targeting·Pawandeep Kaur, Diptiman Choudhury
Mar 25, 2018·European Journal of Pharmacology·Subramanyam DasariGnanasekar Munirathinam
Mar 13, 2021·Journal of Ovarian Research·Parinaz ZivarpourJamal Hallajzadeh
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nabil M Abdel-HamidDaniah Muneam Hamid
Jul 3, 2021·International Journal of Molecular Sciences·Mariia Zadorozhna, Domenica Mangieri
Aug 17, 2021·Nutrition and Cancer·Deepa S Mandlik, Satish K Mandlik

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