Aqueous HPMCAS coatings: effects of formulation and processing parameters on drug release and mass transport mechanisms

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
F SiepmannR Bodmeier

Abstract

The major aim of the present work was to study the effects of various formulation and processing parameters on the resulting drug release kinetics from theophylline matrix pellets coated with aqueous hydroxypropyl methylcellulose acetate succinate (HPMCAS) dispersions. The plasticizer content, coating level and curing conditions significantly affected the release patterns in 0.1 M HCl, whereas no major effects were observed in phosphate buffer, pH 7.4. Due to the significant size of the HPMCAS particles (being in the micrometer range), their coalescence was particularly crucial and not complete upon coating. Consequently, at low coating levels continuous water-filled channels connected the bead cores with the release medium through which the drug could rapidly diffuse, resulting in high release rates even at low pH. In contrast, at high coating levels such continuous connections did not exist (due to the increased number of polymer particle layers), and drug release was controlled by diffusion through the macromolecular network resulting in much lower release rates in 0.1 M HCl. Importantly, pellet curing at elevated temperature and ambient relative humidity or exposure to elevated relative humidity at room temperature did not ...Continue Reading

References

Oct 1, 1989·Journal of Pharmaceutical Sciences·R Bodmeier, H G Chen
May 11, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K Thoma, K Bechtold
May 9, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R O Williams, J Liu
Sep 21, 2000·Advances in Colloid and Interface Science·P A StewardM C Wilkinson
Jan 5, 2002·Pharmaceutical Development and Technology·R O Williams, J Liu
Mar 7, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jiping Liu, Robert O Williams
Oct 3, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jiping Liu, Robert O Williams
Sep 3, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·F LecomteR Bodmeier

❮ Previous
Next ❯

Citations

Nov 26, 2010·Critical Reviews in Food Science and Nutrition·S S KuangA M Crean
Dec 11, 2013·AAPS PharmSciTech·Preetanshu PandeyLinda A Felton
May 28, 2011·Drug Development and Industrial Pharmacy·Hollie F BruceLinda A Felton
Dec 2, 2008·Drug Development and Industrial Pharmacy·Dmytro BarbashLinda Felton
Jan 17, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Susanne MuschertJuergen Siepmann
Jan 13, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·S MuschertJ Siepmann
Dec 11, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·F SiepmannJ Siepmann
Apr 25, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Caroline Désirée Kablitz, Nora Anne Urbanetz
Mar 30, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·F SiepmannJ Siepmann
Jun 12, 2012·International Journal of Pharmaceutics·Lucia ZemaAndrea Gazzaniga
Dec 5, 2017·Pharmaceutical Development and Technology·Nizar Al-ZoubiAl-Sayed Sallam
Apr 26, 2019·AAPS PharmSciTech·Barbara Santos SilvaRyan Gosselin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
F SiepmannJ Siepmann
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
C Wu, J W McGinity
Journal of Controlled Release : Official Journal of the Controlled Release Society
F SiepmannJ Siepmann
Journal of Pharmaceutical Sciences
G S Banker
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
F SiepmannJ Siepmann
© 2022 Meta ULC. All rights reserved