Aqueous humor and plasma adiponectin levels in proliferative diabetic retinopathy patients

Current Eye Research
Danna MaoBo Lei

Abstract

To study whether aqueous humor (AH) and plasma adiponectin (APN) levels were altered in proliferative diabetic retinopathy (PDR). After excluding subjects with hypertension, hyperlipidaemia, nephropathy, coronary heart disease, heart and renal failure, 20 consecutive type 2 diabetes mellitus (DM) PDR patients and 20 consecutive age-matched non-diabetic and senile cataract (non-DM) controls were enrolled in this study. AH APN and plasma APN concentrations were determined by enzyme-linked immunosorbent assay (ELISA). The expression of AdipoR1/R2 mRNA in peripheral blood mononuclear cells (PBMCs) was measured by real-time polymerase-chain reaction (PCR). The correlations between two parameters, including plasma and AH APN, AdipoR1/R2, plasma insulin and plasma glucose, were analyzed by Pearson's correlation. In non-DM subjects, the APN concentration in AH was 1.26 ± 0.56 ng/ml, approximately 1/2500 of that in plasma (3.15 ± 1.36 μg/ml). The averaged AH APN concentration in PDR patients was significant higher than that of the non-DM controls (5.29 ± 4.09 ng/ml vs. 1.26 ± 0.56 ng/ml, p < 0.001). Plasma total APN was not correlated with AH APN in the PDR patients, controls or all subjects. No significant difference was observed in pl...Continue Reading

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Citations

Aug 12, 2014·BioMed Research International·Ersilia NigroAurora Daniele
Dec 20, 2014·Journal of Diabetes Research·Ying-Jung HsuChang-Hao Yang
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Jun 11, 2021·Translational Vision Science & Technology·Hu XiaoXiao Yan Ding

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