Abstract
To study whether aqueous humor (AH) and plasma adiponectin (APN) levels were altered in proliferative diabetic retinopathy (PDR). After excluding subjects with hypertension, hyperlipidaemia, nephropathy, coronary heart disease, heart and renal failure, 20 consecutive type 2 diabetes mellitus (DM) PDR patients and 20 consecutive age-matched non-diabetic and senile cataract (non-DM) controls were enrolled in this study. AH APN and plasma APN concentrations were determined by enzyme-linked immunosorbent assay (ELISA). The expression of AdipoR1/R2 mRNA in peripheral blood mononuclear cells (PBMCs) was measured by real-time polymerase-chain reaction (PCR). The correlations between two parameters, including plasma and AH APN, AdipoR1/R2, plasma insulin and plasma glucose, were analyzed by Pearson's correlation. In non-DM subjects, the APN concentration in AH was 1.26 ± 0.56 ng/ml, approximately 1/2500 of that in plasma (3.15 ± 1.36 μg/ml). The averaged AH APN concentration in PDR patients was significant higher than that of the non-DM controls (5.29 ± 4.09 ng/ml vs. 1.26 ± 0.56 ng/ml, p < 0.001). Plasma total APN was not correlated with AH APN in the PDR patients, controls or all subjects. No significant difference was observed in pl...Continue Reading
References
Nov 1, 1975·The British Journal of Ophthalmology·J Cunha-VazA J Campos
Sep 1, 1991·Neuron·B Ranscht, M T Dours-Zimmermann
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C EnglerH Lund-Andersen
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
May 4, 2001·Diabetes·K HottaY Matsuzawa
Jul 20, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·J Spranger, A F Pfeiffer
Feb 21, 2002·Trends in Endocrinology and Metabolism : TEM·Anders H BergPhilipp E Scherer
Oct 18, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N Stefan, M Stumvoll
Nov 19, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Olavi Ukkola, Merja Santaniemi
Nov 28, 2002·JAMA : the Journal of the American Medical Association·Matthew J Sheetz, George L King
Mar 4, 2003·European Journal of Endocrinology·Juan J Díez, Pedro Iglesias
Apr 26, 2003·BMJ : British Medical Journal·Peter J Watkins
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Jul 25, 2003·The Journal of Biological Chemistry·Hironori WakiTakashi Kadowaki
Jul 14, 2004·European Journal of Endocrinology·Mahmut Ilker YilmazMetin Ozata
Dec 24, 2004·Diabetes·Barbora Vozarova de CourtenJohanna K Wolford
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Aug 4, 2005·Diabetologia·J FrystykA Flyvbjerg
Dec 16, 2005·Nature·Ray F Gariano, Thomas W Gardner
Jan 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Katarina KosSudhesh Kumar
Jan 24, 2007·Diabetologia·C M KusminskiP E Scherer
May 1, 2007·FEBS Letters·Puran S BoraNalini S Bora
Jul 12, 2007·American Journal of Physiology. Endocrinology and Metabolism·Markus NeumeierChrista Buechler
Aug 6, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·B ZietzA Schäffler
Apr 4, 2009·Circulation Research·Akiko HiguchiNoriyuki Ouchi
Apr 20, 2010·Progress in Retinal and Eye Research·M El SanharawiF Behar-Cohen
May 14, 2010·Investigative Ophthalmology & Visual Science·Uttio Roy ChowdhuryMichael P Fautsch
Citations
Aug 12, 2014·BioMed Research International·Ersilia NigroAurora Daniele
Dec 20, 2014·Journal of Diabetes Research·Ying-Jung HsuChang-Hao Yang
Mar 5, 2013·Experimental Eye Research·Ciro CostagliolaAntonio Porcellini
Apr 2, 2015·Acta Ophthalmologica·Ho Sik HwangEun Chul Kim
Feb 1, 2013·Mediators of Inflammation·Roberto dell'OmoCiro Costagliola
Mar 31, 2015·Indian Journal of Pharmacology·Vidhya Srinivasan, K N Sulochana
May 8, 2016·Biochimica Et Biophysica Acta·Zhongjie FuLois E H Smith
Sep 23, 2016·Human Genetics·Jinlu ZhangLiping Yang
Feb 15, 2019·Eye·In Cheol HwangJoon Mo Kim
Feb 27, 2020·International Journal of Molecular Sciences·Zhongjie FuLois E H Smith
Jan 29, 2017·International Ophthalmology·Serpil YazganAtilla Alpay
Jan 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anri NishinakaHideaki Hara
Jun 11, 2021·Translational Vision Science & Technology·Hu XiaoXiao Yan Ding
Nov 16, 2021·PloS One·Hyun Seung YangSangkyung Choi