Aqueous outflow imaging techniques and what they tell us about intraocular pressure regulation.

Eye
Jed A LusthausKeith R Martin

Abstract

Recent advances in the medical and surgical management of open-angle glaucoma have increased the number of treatment options available. Several new intraocular pressure (IOP)-lowering treatments target the conventional aqueous outflow (AO) system. However, success rates are variable and outcomes in individual patients are often difficult to predict. Variable treatment responses remain unexplained and highlight deficiencies in our current understanding of AO regulation and IOP homeostasis. Imaging is often relied upon to confirm diagnoses and monitor treatment responses in other ocular and systemic pathologies. As yet no suitable AO imaging tool has been developed to fulfil this role in glaucoma. A variety of imaging techniques have been used to study the AO tracts of humans and animals in ex vivo and in vivo eyes. In this review, results from novel imaging techniques that assess aqueous drainage through the episcleral venous system are considered and we argue these provide new insights into AO regulation. We suggest that the ability to objectively measure AO responses to interventions would be a significant clinical advance, and we have demonstrated that this can be achieved with direct visualisation of aqueous drainage. We pre...Continue Reading

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Citations

Nov 13, 2020·Eye·Timothy Y Y Lai

Methods Mentioned

BETA
imaging techniques
electron microscopy
imaging technique
confocal microscopy
mechanical dilation
scanning electron microscopy
imaging
light scattering
X-ray
scanning electron

Related Concepts

Diagnosis
Diagnostic Imaging
Drainage Procedure
Eye
Glaucoma
Glaucoma, Open-Angle
Physiologic Intraocular Pressure
Pathology
Imaging Techniques
Intraocular Pressure Finding

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