Aqueous semaphorin 3A level correlates with retinal macular oedema and ganglion cell degeneration in patients with retinal vein occlusion

Acta Ophthalmologica
Shengxiang GuoJingming Li

Abstract

To investigate the semophorin 3A (SEMA3A) level in aqueous humor of patients with retinal vein occlusion (RVO) and explore the correlation of SEMA3A with macular oedema and ganglion cell degeneration in RVO. This comparative study prospectively included 41 consecutive patients (41 eyes) with RVO who had intravitreal anti-VEGF injections from March 2014 to March 2015 for cystoid macular oedema (CME) or neovascular glaucoma (NVG). The patients were divided into three groups according to the fluorescein angiograghy (FFA): central retinal vein occlusion (CRVO) group (n = 15), branch retinal vein occlusion (BRVO) group (n = 15) and NVG group (secondary to CRVO, n = 11). The patients who had undergone cataract surgery (n = 16) during the same period served as controls. The SEMA3A concentration in aqueous humor collected before the initial anti-VEGF injection was determined by enzyme-linked immunosorbent assay (ELISA). Central retinal thickness (CRT), cube volume (CV) and ganglion cell-inner plexiform layer (GC-IPL) thickness was analysed by spectral-domain optical coherence tomography (SD-OCT). Semaphorin 3A level in CRVO group (1.52 ± 1.23 ng/ml) and NVG group (1.67 ± 0.98 ng/ml) were significantly higher than the control group (0.6...Continue Reading

References

Oct 12, 2002·The Journal of Biological Chemistry·Anat ShirvanArieh S Solomon
May 25, 2005·Neuroscience Letters·Takao YasuharaIsao Date
Nov 25, 2006·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkPäivi H Miskala
May 17, 2007·The British Journal of Ophthalmology·Masafumi OtaNagahisa Yoshimura
Oct 28, 2008·Cellular and Molecular Life Sciences : CMLS·L RothD Bagnard
Aug 13, 2010·Developments in Ophthalmology·Wolf BuehlUrsula Schmidt-Erfurth
Oct 2, 2014·The Journal of Clinical Investigation·Agnieszka DejdaPrzemyslaw Sapieha
Jun 16, 2015·Current Drug Targets·Claudio CampaPaolo Perri
Oct 16, 2015·Investigative Ophthalmology & Visual Science·Hyung-Bin LimJung-Yeul Kim
Oct 27, 2015·Developments in Ophthalmology·Shane J Havens, Vikas Gulati
Feb 24, 2016·The British Journal of Ophthalmology·Rayan A AlshareefJay Chhablani
Jun 9, 2016·Investigative Ophthalmology & Visual Science·Soo Hyun KwonDong Ho Park
Mar 8, 2018·The British Journal of Ophthalmology·Dominika PodkowinskiUrsula Schmidt-Erfurth

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Citations

Feb 25, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Xiaoling WangChangzheng Chen

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