Aqueous solubilization of furosemide by supramolecular complexation with 4-sulphonic calix[n]arenes

The Journal of Pharmacy and Pharmacology
Wenzhan Yang, Melgardt M de Villiers

Abstract

The solubilization of the practically water insoluble drug furosemide by guest:host inclusion complexation with 4-sulphonic calix[n]arenes has been reported. The 4-sulphonic calix[n]arenes are water-soluble phenolic cyclooligomers that form inclusion complexes with neutral molecules. The solubility of furosemide in acidic (pH < 4) aqueous solutions containing increasing concentrations of the calixarenes was determined at 30 degrees C and the concentration of furosemide in solution was determined by HPLC. Results showed that the molecular size of the 4-sulphonic calix[n]arenes and the concentration of the calix[n]arenes significantly influenced the increase in the solubility of furosemide. 4-Sulphonic calix[6]arene improved the solubility of furosemide the most (+/-104%) followed by 4-sulphonic calix[8]arene (+/-84-102%), while 4-sulphonic calix[4]arene increased the solubility of furosemide the least (+/-73-81%). The increase in furosemide solubility afforded by the calixarenes was most probably the result of the incorporation of the non-polar portions of the furosemide molecule into the non-polar cavities of the calixarenes similar to furosemide:cyclodextrin complexes. The driving force for this interaction was the reduction i...Continue Reading

References

Jan 1, 1984·European Journal of Clinical Pharmacology·M M HammarlundB Odlind
Sep 5, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elisma SpamerJohannes P Venter
Mar 5, 2003·Journal of Biomaterials Applications·Marilena Vlachou, George Papaïoannou
Dec 21, 2004·Drug Development and Industrial Pharmacy·N Ozdemir, S Ordu
Apr 1, 1986·Journal of the American Chemical Society·S ShinkaiO Manabe

❮ Previous
Next ❯

Citations

Jun 8, 2006·Chemical Communications : Chem Comm·Florent PerretAnthony W Coleman
Aug 19, 2007·Chemical Communications : Chem Comm·Suk Fun ChinMartin Saunders
Mar 26, 2008·Chemical Communications : Chem Comm·Ruth LalorSusan E Matthews
Sep 30, 2009·Chemical Communications : Chem Comm·Oksana Danylyuk, Kinga Suwinska
Apr 16, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Seán T MeallyLeigh F Jones
Jul 6, 2007·Bioinorganic Chemistry and Applications·Princy Jose, Shobana Menon
Apr 4, 2014·Advances in Pharmacological Sciences·Candice PullenAndrew Fenning
Mar 1, 2012·Drug and Chemical Toxicology·Bahram Mokhtari, Kobra Pourabdollah
Aug 9, 2013·Journal of Pharmaceutical Sciences·Elena V UkhatskayaThorsteinn Loftsson
Nov 15, 2011·Journal of Pharmaceutical Sciences·N Rajesh GoudAshwini Nangia
Jun 27, 2009·Magnetic Resonance in Chemistry : MRC·Lucas Micquéias ArantesSergio Antonio Fernandes
Jan 23, 2020·Angewandte Chemie·Yu-Chen PanDong-Sheng Guo
Feb 9, 2010·The Journal of Physical Chemistry. B·Mónika Megyesi, László Biczók

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Wenzhan Yang, Melgardt M de Villiers
Bioinorganic Chemistry and Applications
Princy Jose, Shobana Menon
© 2022 Meta ULC. All rights reserved