Arab gene geography: From population diversities to personalized medical genomics

Global Cardiology Science & Practice
Ghazi O TadmouriLotfi Chouchane

Abstract

Genetic disorders are not equally distributed over the geography of the Arab region. While a number of disorders have a wide geographical presence encompassing 10 or more Arab countries, almost half of these disorders occur in a single Arab country or population. Nearly, one-third of the genetic disorders in Arabs result from congenital malformations and chromosomal abnormalities, which are also responsible for a significant proportion of neonatal and perinatal deaths in Arab populations. Strikingly, about two-thirds of these diseases in Arab patients follow an autosomal recessive mode of inheritance. High fertility rates together with increased consanguineous marriages, generally noticed in Arab populations, tend to increase the rates of genetic and congenital abnormalities. Many of the nearly 500 genes studied in Arab people revealed striking spectra of heterogeneity with many novel and rare mutations causing large arrays of clinical outcomes. In this review we provided an overview of Arab gene geography, and various genetic abnormalities in Arab populations, including disorders of blood, metabolic, circulatory and neoplasm, and also discussed their associated molecules or genes responsible for the cause of these disorders. A...Continue Reading

References

Sep 1, 1991·American Journal of Physical Anthropology·H WalterG F De Stefano
Jan 1, 1987·Nature·R L CannA C Wilson
Jan 1, 1988·Human Genetics·M P GomesA Cao
Mar 1, 1985·American Journal of Medical Genetics·J MaloufV M Der Kaloustian
Jan 1, 1985·Hemoglobin·S Fattoum, S Abbes
Mar 1, 1996·Annals of Tropical Paediatrics·G A NiaziE Beutler
Jul 21, 1998·Annals of the New York Academy of Sciences·N JassimS A Arrayed
Aug 10, 1999·European Journal of Human Genetics : EJHG·Y PataelE Friedman
Sep 28, 2000·Journal of Human Evolution·J D Irish
Dec 29, 2000·Nature·M IngmanU Gyllensten
Jun 21, 2001·Annals of Human Genetics·P A UnderhillL L Cavalli-Sforza
Sep 13, 2001·BMC Genetics·N Maca-MeyerV M Cabrera
Jan 16, 2002·Current Opinion in Oncology·Kornelia Polyak
Oct 5, 2002·Clinical Microbiology Reviews·Richard Carter, Kamini N Mendis
Apr 11, 2003·American Journal of Physical Anthropology·G Lucotte, G Mercier
Apr 12, 2003·Science·Deirdre A JoyXin-zhuan Su
Oct 22, 2003·Journal of Medical Genetics·P J CouckeA De Paepe
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Amel Haj KhelilPascale Perrin
Feb 20, 2004·American Journal of Human Genetics·J R LuisR J Herrera
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Khaled K Abu-AmeroNduna Dzimiri
Jun 18, 2004·American Journal of Human Genetics·Barbara ArrediChris Tyler-Smith
Feb 16, 2005·Human Mutation·Yun WangAnne-Lise Børresen-Dale
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Douglas A LevineJeff Boyd
Jul 8, 2005·American Journal of Human Genetics·Dominic P Kwiatkowski
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annie O ChanStanley R Hamilton
Dec 13, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Ayman A El-MenyarJassim Al-Suwaidi
Dec 27, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·Besma Yacoubi LoueslatiAmel Ben Ammar Elgaaied
Feb 21, 2006·Journal of Biomedicine & Biotechnology·Amein K Al-AliFoad Qaw
Apr 26, 2006·Human Heredity·Ana M Pérez-MirandaRene J Herrera
Jul 11, 2006·American Journal of Human Genetics·Hua LiuFrançois Balloux
Sep 5, 2006·Human Genetics·Ramana GutalaChris Tyler-Smith

❮ Previous
Next ❯

Citations

Mar 21, 2019·International Journal of Immunogenetics·Jerzy K KulskiGuan K Tay
Jan 21, 2017·Scientific Reports·Prashantha HebbarOsama Alsmadi
Feb 19, 2020·Genome Biology and Evolution·Muthukrishnan EaaswarkhanthThangavel Alphonse Thanaraj
Nov 18, 2016·Frontiers in Human Neuroscience·Nsreen AlahmadiLutz Jäncke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.