Arabidopsis ALIX is required for the endosomal localization of the deubiquitinating enzyme AMSH3

Proceedings of the National Academy of Sciences of the United States of America
Kamila KalinowskaErika Isono

Abstract

Ubiquitination is a signal for various cellular processes, including for endocytic degradation of plasma membrane cargos. Ubiquitinating as well as deubiquitinating enzymes (DUBs) can regulate these processes by modifying the ubiquitination status of target protein. Although accumulating evidence points to the important regulatory role of DUBs, the molecular basis of their regulation is still not well understood. Associated molecule with the SH3 domain of signal transduction adaptor molecule (STAM) (AMSH) is a conserved metalloprotease DUB in eukaryotes. AMSH proteins interact with components of the endosomal sorting complex required for transport (ESCRT) and are implicated in intracellular trafficking. To investigate how the function of AMSH is regulated at the cellular level, we carried out an interaction screen for the Arabidopsis AMSH proteins and identified the Arabidopsis homolog of apoptosis-linked gene-2 interacting protein X (ALIX) as a protein interacting with AMSH3 in vitro and in vivo. Analysis of alix knockout mutants in Arabidopsis showed that ALIX is essential for plant growth and development and that ALIX is important for the biogenesis of the vacuole and multivesicular bodies (MVBs). Cell biological analysis re...Continue Reading

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Feb 3, 2016·Molecular Plant·Yong CuiLiwen Jiang
Nov 23, 2017·Journal of Experimental Botany·Kamila Kalinowska, Erika Isono
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Jul 8, 2021·Plant & Cell Physiology·Noriyoshi YagiMasayoshi Nakamura
Oct 12, 2021·The Plant Cell·Byung-Ho KangBethany Karlin Zolman

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