Arabidopsis choline transporter-like 1 (CTL1) regulates secretory trafficking of auxin transporters to control seedling growth

PLoS Biology
Yuan WangSheng Luan

Abstract

Auxin controls a myriad of plant developmental processes and plant response to environmental conditions. Precise trafficking of auxin transporters is essential for auxin homeostasis in plants. Here, we report characterization of Arabidopsis CTL1, which controls seedling growth and apical hook development by regulating intracellular trafficking of PIN-type auxin transporters. The CTL1 gene encodes a choline transporter-like protein with an expression pattern highly correlated with auxin distribution and is enriched in shoot and root apical meristems, lateral root primordia, the vascular system, and the concave side of the apical hook. The choline transporter-like 1 (CTL1) protein is localized to the trans-Golgi network (TGN), prevacuolar compartment (PVC), and plasma membrane (PM). Disruption of CTL1 gene expression alters the trafficking of 2 auxin efflux transporters-Arabidopsis PM-located auxin efflux transporter PIN-formed 1 (PIN1) and Arabidopsis PM-located auxin efflux transporter PIN-formed 3 (PIN3)-to the PM, thereby affecting auxin distribution and plant growth and development. We further found that phospholipids, sphingolipids, and other membrane lipids were significantly altered in the ctl1 mutant, linking CTL1 functi...Continue Reading

References

Mar 1, 1985·The Journal of Cell Biology·P GreenspanS D Fowler
May 1, 1997·Plant Physiology·E GendreauH Höfte
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Feb 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Iris OttenschlägerKlaus Palme
Jan 20, 2004·Plant Physiology·Joshua J BlakesleeAngus S Murphy
Jan 24, 2007·The Plant Cell·Joshua J BlakesleeAngus S Murphy
Mar 11, 2008·Micron : the International Research and Review Journal for Microscopy·Giacomo DiazAngela Maria Falchi
May 1, 2008·Annual Review of Plant Biology·René Benjamins, Ben Scheres
Jul 17, 2008·Traffic·Marisa S Otegui, Christoph Spitzer
Mar 24, 2009·Cell·Steffen Vanneste, Jirí Friml
Mar 25, 2009·The Plant Journal : for Cell and Molecular Biology·Niko GeldnerJoanne Chory
Jun 30, 2009·Trends in Plant Science·Benjamin PéretMalcolm J Bennett
Jul 28, 2009·Development·Jan Petrásek, Jirí Friml
Jan 30, 2010·Development·Petra ZádníkováEva Benková
Feb 26, 2010·Cold Spring Harbor Perspectives in Biology·Enrico ScarpellaMiltos Tsiantis
Jun 15, 2011·Cell Research·Marta ZwiewkaJiří Friml
Aug 9, 2011·Current Opinion in Plant Biology·Francisca C ReyesMarisa S Otegui
Jan 11, 2012·Biochimica Et Biophysica Acta·Michal A SurmaKai Simons
Sep 1, 2012·Journal of Cell Science·Anthony L Contento, Diane C Bassham
Jan 3, 2013·The Plant Journal : for Cell and Molecular Biology·Haibing YangAngus S Murphy
Feb 28, 2013·Nature Communications·Yozo OkazakiKazuki Saito
Mar 7, 2013·Journal of Integrative Plant Biology·William J LucasPradeep Kachroo
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yohann BouttéRishikesh P Bhalerao
Nov 10, 2013·Frontiers in Plant Science·Mohamad AbbasMiguel A Blázquez

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Citations

Apr 26, 2018·International Journal of Molecular Sciences·Abu Imran BabaÁgnes Cséplő
May 10, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stephan Guttinger
Sep 19, 2018·International Journal of Molecular Sciences·Jing-Jing Zhou, Jie Luo
Dec 20, 2019·Brain : a Journal of Neurology·Christina R FagerbergMarica Bakovic
Jan 27, 2019·Plants·Lothar Kalmbach, Ykä Helariutta
Aug 4, 2021·The Plant Journal : for Cell and Molecular Biology·Liang ZhangJinxing Lin

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Methods Mentioned

BETA
nucleotide
GTPases
transgenic
reverse
confocal microscopy
using
PCR
Reverse transcription PCR
Fluorescence

Software Mentioned

ImageJ
Progenesis QI
R

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