Arabidopsis COP1/SPA1 complex and FHY1/FHY3 associate with distinct phosphorylated forms of phytochrome A in balancing light signaling.

Molecular Cell
Yusuke SaijoXing Wang Deng

Abstract

Fine tuning of light signaling is crucial to plant development. Following light-triggered nuclear translocation, the photoreceptor phytochrome A (phyA) regulates gene expression under continuous far-red light and is rapidly destabilized upon red light irradiation by E3 ubiquitin ligases, including COP1. Here we provide evidence that the light signaling repressors SPA proteins contribute to COP1-mediated phyA degradation and that a COP1/SPA1 protein complex is tightly associated with phyA ubiquitination activity. Furthermore, a phosphorylated phyA form accumulates in the nucleus and preferentially associates with the COP1/SPA1 complex. In contrast, underphosphorylated phyA predominantly associates with the phyA-signaling intermediates FHY3 and FHY1. However, COP1 associates with underphosphorylated phyA in the absence of FHY3 or FHY1, suggesting that phyA associations with FHY3 and FHY1 protect underphosphorylated phyA from being recognized by the COP1/SPA complex. We propose that light-induced phyA phosphorylation acts as a switch controlling differential interactions of the photoreceptor with signal propagation or attenuation machineries.

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Citations

May 18, 2010·Plant Molecular Biology·Dimitry Debrieux, Christian Fankhauser
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xunli LuYusuke Saijo
Mar 6, 2010·Plant & Cell Physiology·Yun-Jeong HanJeong-Il Kim
Feb 9, 2013·Plant Physiology·Dimitry DebrieuxChristian Fankhauser
Nov 14, 2013·Journal of Experimental Botany·J J CasalR Sellaro
Aug 9, 2011·Bioscience, Biotechnology, and Biochemistry·Saori YamawakiTakeshi Mizuno
Oct 2, 2012·Annual Review of Genetics·Zhi-Yong WangJia-Ying Zhu
Dec 2, 2015·Cellular and Molecular Life Sciences : CMLS·Motomu EndoAkira Nagatani
Mar 5, 2016·Frontiers in Plant Science·Hamad SiddiquiPaul F Devlin
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Oct 11, 2011·Trends in Plant Science·Hongtao LiuChentao Lin
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Jan 20, 2010·European Journal of Cell Biology·Esther Mirjam Natascha DohmannClaus Schwechheimer
Dec 17, 2008·Current Opinion in Plant Biology·Rossana HenriquesNam-Hai Chua
Oct 30, 2015·Journal of Photochemistry and Photobiology. B, Biology·Parul PariharSheo Mohan Prasad
Sep 19, 2009·The EMBO Journal·Yusuke SaijoPaul Schulze-Lefert
Oct 21, 2010·The New Phytologist·Karl-Josef DietzGary Harris
Feb 28, 2014·The New Phytologist·Miguel de Lucas, Salomé Prat
Feb 12, 2015·Molecular Plant·Hai Wang, Haiyang Wang
Jul 6, 2014·Plant, Cell & Environment·Ferenc Nagy, Seth J Davis
Jul 26, 2014·Current Opinion in Plant Biology·Xi HuangXing Wang Deng
May 10, 2015·Trends in Plant Science·Hai Wang, Haiyang Wang
Mar 31, 2015·Plant Physiology and Biochemistry : PPB·Lisi XieMarie-Theres Hauser
Apr 21, 2012·Plant Signaling & Behavior·Balázs LeitgebAndrás Viczián
May 10, 2011·Current Biology : CB·G Eric SchallerJudith P Armitage
Jun 19, 2012·Trends in Plant Science·On Sun Lau, Xing Wang Deng
Jan 21, 2015·Current Opinion in Plant Biology·Maarten DedeckerGeert De Jaeger

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