Arabidopsis homologue of human transcription factor IIH/nucleotide excision repair factor p44 can function in transcription and DNA repair and interacts with AtXPD

The Plant Journal : for Cell and Molecular Biology
Edward J VonarxBernard A Kunz

Abstract

Eukaryotic general transcription factor (TF) IIH is composed of 10 proteins, seven of which are also required for nucleotide excision repair (NER) of UV radiation-induced DNA damage in human cells and yeast. Plant homologues of the human TFIIH subunits XPB and XPD that function in NER have been isolated but none has been shown to operate in transcription. Here we address the capabilities of Arabidopsis thaliana AtGTF2H2 and AtXPD, homologues of the essential interacting human/yeast TFIIH components p44/Ssl1 and XPD/Rad3, respectively. Expression of AtGTF2H2 or AtXPD cDNAs in yeast ssl1 or rad3 mutants temperature-sensitive for growth due to thermolabile transcription of mRNA restored growth and so transcription at the non-permissive temperature. AtGTF2H2 also complemented the NER deficiency of the corresponding yeast mutant, as measured by full recovery of UV resistance, whereas AtXPD did not despite being necessary for NER in Arabidopsis. UV treatment did not upregulate transcription of AtGTF2H2 or AtXPD in Arabidopsis. Suppression of a yeast translation initiation defect by the ssl1-1 mutation was prevented by expression of AtGTF2H2. Deletion of SSL1 in a yeast strain expressing AtGTF2H2 did not affect growth or confer UV sen...Continue Reading

References

Apr 1, 1987·Mutation Research·M K PierceB A Kunz
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L Naumovski, E C Friedberg
Mar 9, 1995·Nature·D O Morgan
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·L BardwellE C Friedberg
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·R DrapkinD Reinberg
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jan 14, 1998·Plant Molecular Biology·C P JoshiV L Chiang
May 11, 1999·Trends in Plant Science·A B Britt
Feb 8, 2000·The Journal of Biological Chemistry·G S WinklerG Weeda
Mar 22, 2000·Plant Science : an International Journal of Experimental Plant Biology·M LukaszewiczM Boutry
Jul 7, 2000·The Journal of Biological Chemistry·S FribourgB Kieffer
Aug 1, 2000·Mutation Research·S Prakash, L Prakash
Sep 28, 2000·Cell·P SchultzJ M Egly
Dec 29, 2000·Nature·UNKNOWN Arabidopsis Genome Initiative
Apr 25, 2001·The Journal of Biological Chemistry·A Tremeau-BravardJ M Egly
Oct 10, 2001·The Journal of Biological Chemistry·T BorggrefeR D Kornberg
Dec 12, 2001·The Plant Journal : for Cell and Molecular Biology·R M CostaC F Menck
Mar 20, 2002·Nature Reviews. Cancer·E C Friedberg
May 23, 2002·Cell·Sebastian IbenIngrid Grummt
Jun 25, 2002·The Journal of Biological Chemistry·Anass JawhariJean-Marc Egly
Apr 1, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mikael BroschéAke Strid
Jul 11, 2003·Nature·Jian ChenBeat Suter
Sep 23, 2003·The Journal of Biological Chemistry·Yuichiro TakagiRoger D Kornberg
Oct 1, 2003·The EMBO Journal·Thilo RiedlJean-Marc Egly
Oct 11, 2003·Trends in Genetics : TIG·Mario Zurita, Carlos Merino

❮ Previous
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Citations

Jan 17, 2009·Plant Cell Reports·Agustina GentileMarcelo Menossi
Mar 17, 2009·Plant Molecular Biology·Wesam M Al Khateeb, Dana F Schroeder
Oct 26, 2013·Plant Science : an International Journal of Experimental Plant Biology·Valentina LyDana F Schroeder
May 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Phuong Minh NguyenWilliam K Chan
Feb 21, 2014·Plant Cell Reports·Andriy BilichakIgor Kovalchuk
Aug 27, 2011·Biochimica Et Biophysica Acta·Anja MannussHolger Puchta
Aug 19, 2008·Mutation Research·Teresa Roldán-Arjona, Rafael R Ariza
May 23, 2008·The Plant Journal : for Cell and Molecular Biology·Heather J AndersonBernard A Kunz
Mar 3, 2015·TheScientificWorldJournal·Sarvajeet S GillNarendra Tuteja
Dec 22, 2016·Cellular and Molecular Life Sciences : CMLS·Claudia P Spampinato
Nov 12, 2015·Frontiers in Plant Science·Vasilissa Manova, Damian Gruszka
Sep 17, 2020·International Journal of Molecular Sciences·Philippe Johann To Berens, Jean Molinier

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