Arabidopsis inositol phosphate kinases IPK1 and ITPK1 constitute a metabolic pathway in maintaining phosphate homeostasis.

The Plant Journal : for Cell and Molecular Biology
Hui-Fen KuoTzyy-Jen Chiou

Abstract

Emerging studies have suggested that there is a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi ) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to mediate Pi signaling remains unknown. Here, using genetics and InsP profiling combined with Pi -starvation response (PSR) analysis in Arabidopsis thaliana, we showed that the kinase activity of inositol pentakisphosphate 2-kinase (IPK1), an enzyme required for phytate (inositol hexakisphosphate; InsP6 ) synthesis, is indispensable for maintaining Pi homeostasis under Pi -replete conditions, and inositol 1,3,4-trisphosphate 5/6-kinase 1 (ITPK1) plays an equivalent role. Although both ipk1-1 and itpk1 mutants exhibited decreased levels of InsP6 and diphosphoinositol pentakisphosphate (PP-InsP5 ; InsP7 ), disruption of another ITPK family enzyme, ITPK4, which correspondingly caused depletion of InsP6 and InsP7 , did not display similar Pi -related phenotypes, which precludes these InsP species from being effectors. Notably, the level of d/l-Ins(3,4,5,6)P4 was concurrently elevated in both ipk1-1 and itpk1 mutants, which showed a specific correlation with the misregulated...Continue Reading

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Citations

Jul 28, 2018·Plant & Cell Physiology·Pei-Shan ChienTzyy-Jen Chiou
Aug 20, 2019·The New Phytologist·Laura Lorenzo-OrtsMichael Hothorn
Dec 14, 2018·Frontiers in Plant Science·Ringo van WijkTeun Munnik
Dec 11, 2019·Genes·Paweł Sega, Andrzej Pacak
Nov 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yann DesfougèresAdolfo Saiardi
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Caitlin Cridland, Glenda Gillaspy
Jan 11, 2021·Advances in Biological Regulation·Debabrata LahaAdolfo Saiardi
Nov 14, 2020·The Plant Journal : for Cell and Molecular Biology·Devang MehtaR Glen Uhrig
Sep 26, 2019·Journal of Agricultural and Food Chemistry·Muhammad Saad Shoaib KhanQingyao Shu
Mar 19, 2020·ACS Medicinal Chemistry Letters·Gaye WhiteCharles A Brearley
Aug 31, 2018·Journal of Medicinal Chemistry·Hayley WhitfieldCharles A Brearley
Jul 19, 2021·Molecular Plant·Esther RiemerRicardo F H Giehl
Sep 18, 2021·Frontiers in Plant Science·Lindsay C DeMersM A Saghai Maroof

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