Arabidopsis molybdenum cofactor sulfurase ABA3 contributes to anthocyanin accumulation and oxidative stress tolerance in ABA-dependent and independent ways

Scientific Reports
Shunsuke WatanabeMitsunori Seo


Arabidopsis ABA3 is an enzyme involved in the synthesis of the sulfurated form of the molybdenum (Mo) cofactor (MoCo), which is required for the enzymatic activity of so-called Mo enzymes such as aldehyde oxidase (AO) and xanthine dehydrogenase (XDH). It has been reported that AO and XDH are essential for the biosynthesis of the bioactive compounds, ABA and allantoin, respectively. However, aba3 mutants often exhibit pleiotropic phenotypes that are not explained by defects in ABA and/or allantoin biosynthesis, leading us to hypothesize that ABA3 regulates additional metabolic pathways. To reveal the currently unidentified functions of ABA3 we compared transcriptome and metabolome of the Arabidopsis aba3 mutant with those of wild type and a typical ABA-deficient mutant aba2. We found that endogenous levels of anthocyanins, members of the flavonoid group, were significantly lower in the aba3 mutant than in the wild type or the aba2 mutant under oxidative stress. In contrast, mutants defective in the AO and XDH holoenzymes accumulated significantly higher levels of anthocyanins when compared with aba3 mutant under the same conditions. Our findings shed light on a key role of ABA3 in the ABA- and allantoin-independent accumulation ...Continue Reading


Oct 16, 2019·Frontiers in Plant Science·Abrar FelembanSalim Al-Babili
Nov 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shunsuke WatanabeMitsunori Seo


Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Oct 1, 1996·The Plant Journal : for Cell and Molecular Biology·K M Léon-KloosterzielM Koornneef
Dec 1, 1996·The Plant Journal : for Cell and Molecular Biology·Y WuN H Chua
May 1, 1997·Plant Physiology·S H SchwartzJ A Zeevaart
Jun 6, 1998·Plant & Cell Physiology·H SekimotoT Koshiba
Sep 6, 2000·The Plant Journal : for Cell and Molecular Biology·M SeoT Koshiba
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M SeoT Koshiba
Apr 19, 2002·Current Opinion in Plant Biology·Brenda Winkel-Shirley
Jun 5, 2002·The Plant Cell·Ruth R FinkelsteinC D Rock
Aug 13, 2002·The Plant Cell·Miguel González-GuzmánPedro L Rodríguez
Jul 15, 2003·Plant Physiology·Gabriela Carolina PagnussatLorenzo Lamattina
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·Wilbur H. Campbell
Apr 14, 2004·Journal of Plant Physiology·Adriana Szmidt-JaworskaJan Kopcewicz
Jul 1, 2004·FEBS Letters·Lara DonaldsonKatherine Denby
Oct 7, 2004·Trends in Plant Science·Ron MittlerFrank Van Breusegem
Dec 9, 2004·Doklady. Biochemistry and Biophysics·E P Gus'kovYu A Zhdanov
Jan 31, 2006·The Plant Journal : for Cell and Molecular Biology·Paul E VersluesJian-Kang Zhu
Feb 8, 2006·The Plant Journal : for Cell and Molecular Biology·Frans J M Maathuis
May 4, 2006·Annual Review of Plant Biology·Rita ZrennerRalf Boldt
Jul 25, 2007·Current Opinion in Plant Biology·Edward E Farmer, Céline Davoine
Jan 1, 1997·Trends in Cell Biology·S A BarnesN H Chua
Feb 13, 2008·The Plant Journal : for Cell and Molecular Biology·Galina BrychkovaMoshe Sagi
Sep 18, 2008·Journal of Experimental Botany·Mark N MerzlyakK Razi Naqvi
Jun 27, 2009·Phytochemistry·Martin J Mueller, Susanne Berger
Aug 14, 2009·Nature·Günter SchwarzMarkus W Ribbe

Related Concepts

Biological Adaptation to Stress
Enzymes, antithrombotic
Mutant Proteins
Oxidative Stress
Oxidative Stress Analysis
ABA3 protein, Arabidopsis
Molybdenum cofactor

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.