Arabidopsis thaliana and Pseudomonas Pathogens Exhibit Stable Associations over Evolutionary Timescales

Cell Host & Microbe
Talia L KarasovDetlef Weigel

Abstract

Crop disease outbreaks are often associated with clonal expansions of single pathogenic lineages. To determine whether similar boom-and-bust scenarios hold for wild pathosystems, we carried out a multi-year, multi-site survey of Pseudomonas in its natural host Arabidopsis thaliana. The most common Pseudomonas lineage corresponded to a ubiquitous pathogenic clade. Sequencing of 1,524 genomes revealed this lineage to have diversified approximately 300,000 years ago, containing dozens of genetically identifiable pathogenic sublineages. There is differentiation at the level of both gene content and disease phenotype, although the differentiation may not provide fitness advantages to specific sublineages. The coexistence of sublineages indicates that in contrast to crop systems, no single strain has been able to overtake the studied A. thaliana populations in the recent past. Our results suggest that selective pressures acting on a plant pathogen in wild hosts are likely to be much more complex than those in agricultural systems.

Citations

Sep 19, 2018·Nature Ecology & Evolution·Erica M Goss, Sujan Timilsina
May 28, 2019·The New Phytologist·Lamprinos FrantzeskakisRalph Panstruga
Jul 25, 2019·Evolution; International Journal of Organic Evolution·Liana T BurghardtPeter Tiffin
Sep 5, 2020·Critical Reviews in Microbiology·Léa GirardRené De Mot
Jun 13, 2020·Annual Review of Microbiology·Connor R FitzpatrickJeffery L Dangl
Sep 11, 2020·Evolutionary Applications·Kristina Karlsson GreenÅsa Lankinen
Jan 5, 2020·Nature Ecology & Evolution·Thorsten ThiergartStéphane Hacquard
Feb 23, 2020·F1000Research·Alexandra Tabrett, Matthew W Horton
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Mar 14, 2021·Cell Host & Microbe·Katarzyna ParysYoussef Belkhadir
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Jul 2, 2021·Nature Microbiology·Sebastian PfeilmeierJulia A Vorholt
Aug 26, 2021·Evolution; International Journal of Organic Evolution·Maridel FredericksenDieter Ebert
Sep 10, 2021·Molecular Biology and Evolution·Gautam ShirsekarDetlef Weigel
Nov 13, 2021·Applied Microbiology and Biotechnology·Chuanfa WuTida Ge
Dec 12, 2021·Nature Communications·Fantin MesnyStéphane Hacquard

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Datasets Mentioned

BETA
PRJNA430505
PRJEB24450

Methods Mentioned

BETA
amplicon sequencing
PCR

Software Mentioned

samtools
PerMANOVA
Mothur
VSEARCH
ADE4
RAxML
AUGUSTUS
TMRCA
panX
ClonalFrameML

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